Journal of the Korean Ophthalmological Society 2000;41(6):1265-1271.
Published online June 1, 2000.
Effects of Topically Applied Na-Hyaluronan on Epithelial Healing and Aqueous Composition in Experimental Corneal Alkali Wounds.
Yoo Kyung Park, Jang Hyun Chung
Department of Ophthalmology, College of Medicine, Hallym University, Kangdong Sacred Heart Hospital, Korea.
가토 각막 알칼리 화상에서 Na-Hyaluronan 국소 점안이 각막 상피 치유와 방수 조성에 미치는 영향
박유경(Yoo Kyung Park),정장현(Jang Hyun Chung)
The effects of topical sodium-hyaluronan (Na-HA)on the epithelial healing and aqueous compositions were examined in the repair process of experimen-tal corneal alkali wounds.Corneal alkali wounds were produced in one eye of each rabbit by applying a 5.5 mmround filter paper soaked in 1N NaOH onto the central cornea for 60 seconds.Then the eyes were treated topically with either 1%Na-HA (the treatment group)or a phosphate buffered saline (PBS) (the control group)4 times per day.The epithelial healing was assessed using a quantitative method and the changes of the concentration of ascorbic acid and glucose in aqueous were evaluated.The initial epithelial healing rate was similar between 1%Na-HA treated and control groups and the later healing was enhanced in the treated group but statistically insignificant.The concentrations of ascorbic acid and glucose in aqueous humor are not statistically different in the early phase, but ascorbic acid concentration in later healing phase was higher in the treated group when compared with the control group.The present findings in dicate that topical-ly applied 1%Na-HA affects late epithelial healing and ascorbic acid concentration in aqueous humor during the repair process after corneal alkali wounds.
Key Words: Cornea;Alkali wound;Epithelium;Ascorbic acid;Na-Hyaluronan

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