Journal of the Korean Ophthalmological Society 2000;41(5):1033-1039.
Published online May 1, 2000.
Effects of Topically Applied 0.1%Dexamethasone on Endothelial Healing and Aqueous Composition Following Experimental Corneal Alkali Wounds.
Yoo Kyung Park, Jang Hyun Chung
Department of Ophthalmology, Ewha Womans University, Mokdong Hospital, Seoul, Korea.
가토 각막 알칼리 화상에서 0.1%Dexamethasone 국소 점안이 각막 내피 치유와 방수 조성에 미치는 영향
박유경(Yoo Kyung Park),정장현(Jang Hyun Chung)
The effects of topical dexamethasone on the endothelial healing and the change of aqueous composition were examined in the repair process of experimental corneal alkali wounds. Corneal alkali wounds were induced, then the eyes were treated topically with either 0.1%dexamethasone or abalanced salt solution[BSS]4 times per day for 8 weeks. Endothelial wound morphometry was performed after alizarin red and trypan blue staining. The concentrations of ascorbic acid, glucose, and the ions, Na, K , Ca2 and Mg2 , were measured in the aqueous humor. Endothelial healing in control corneas showed a biphasic pattern of healing:an initial short-term healing for the first week and then a late long-term healing following a secondary endothelial breakdown. Topical administration of 0.1%dexamethasone deterred endothelial healing during the early period and prevented secondary endothelial breakdown. Total repair process of endothelium was accelerated by the dexamethasone treatment. Among the various components of the aqueous humor examined, ascorbic acid seemed most sensitive to change caused by the alkali injury and dexametha-sone treatment. The present data indicate that dexamethasone may have a therapeutic potential in the management of endothelial healing after corneal alkali injury.
Key Words: Alkali wound;Aqueous;Cornea;Dexamethasone;Endothelial healing

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