J Korean Ophthalmol Soc > Volume 49(4); 2008 > Article
Journal of the Korean Ophthalmological Society 2008;49(4):651-660.
DOI: https://doi.org/10.3341/jkos.2008.49.4.651    Published online April 15, 2008.
The Efficacy of Intravitreal Gatifloxacin in Experimental S. epidermidis Endophthalmitis.
Soo Young Lee, Eun Hye Ryu, Sun Kyung Moon, Hyun Jin Kim, So Youn Woo, Min Sun Cho, Hyoung Jun Koh
1Department of Ophthalmology, Ewha Womans University School of Medicine, Seoul, Korea. sylee09@ewha.ac.kr
2Department of Microbiology, Ewha Womans University School of Medicine, Seoul, Korea.
3Department of Pathology, Ewha Womans University School of Medicine, Seoul, Korea.
4Department of Ophthalmology, Yonsei University College of Medicine, Seoul, Korea.
실험적 피부포도알균 안내염에서 가티플록사신의 유리체강내 주사의 효과
이수영1ㆍ류은혜1ㆍ문선경1ㆍ김현진1ㆍ우소연2ㆍ조민선3ㆍ고형준4
Department of Ophthalmology, Ewha Womans University School of Medicine1, Seoul, Korea / Department of Microbiology, Ewha Womans University School of Medicine2, Seoul, Korea / Department of Pathology, Ewha Womans University School of Medicine3, Seoul, Korea / Department of Ophthalmology, Yonsei University College of Medicine4, Seoul, Korea
Abstract
PURPOSE
To compare the efficacy of intravitreal gatifloxacin with intravitreal vancomycin in the treatment of Staphylococcus epidermidis endophthalmitis in a rabbit model. METHODS: Albino rabbits (n=30), infected with an intravitreal inoculum of S. epidermidis (10(5) colony forming unit/0.1 mL), were divided into 6 groups (n=5). Groups I and IV received 200 microgram/0.1 mL of intravitreal gatifloxacin, and groups II and V were injected 1000 microgram/0.1 mL of vancomycin intravitreally. Intravitreal balanced salt solutions (untreated control) were given to Groups III and VI. Intravitreal antibiotic therapy commenced 24 hours after bacterial inoculation. The bactericidal efficacy was determined by electroretinography (ERG), clinical grading, bacterial culture of vitreous aspirates and histopathologic grading. ERGs and clinical gradings were performed only for groups I, II, and III and bacterial cultures were done only for groups IV, V, and VI. RESULTS: Eyes in the gatifloxacin groups showed similar appearance to those in the vancomycin treated groups clinically, histologically, and functionally as proved with ERG. All aspirates from the gatifloxacin and vancomycin groups were culture negative at 5 days after bacterial inoculation, whereas all eyes in the untreated control group were culture positive. CONCLUSIONS: This study demonstrated that intravitreal injection of 200 microgram /0.1mL gatifloxacin appeared to be equally effective compared to intravitreal 1000 microgram /0.1 mL vancomycin in the treatment of S. epidermidis endophthalmitis. If proven safe and efficacious after further study in humans, intravitreal injection of gatifloxacin could be considered an effective alternative to vancomycin for the treatment of S. epidermidis endophthalmitis.
Key Words: Endophthalmitis;Gatifloxacin;Intravitreal antibiotics;Staphylococcus epidermidis;Vancomycin


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