J Korean Ophthalmol Soc > Volume 58(4); 2017 > Article
Journal of the Korean Ophthalmological Society 2017;58(4):401-407.
DOI: https://doi.org/10.3341/jkos.2017.58.4.401    Published online April 15, 2017.
The Effect of Intravitreal Injection on the Corneal Endothelium.
So Jung Ryu, Yong Un Shin, Min Ho Kang, Mincheol Seong, Hee Yoon Cho
Department of Ophthalmology, Guri Hospital, Hanyang University College of Medicine, Guri, Korea. hycho@hanyang.ac.kr
유리체강 내 약물주입술이 각막내피세포에 미치는 영향
한양대학교 의과대학 구리병원 안과학교실
Correspondence:  Hee Yoon Cho,
Email: hycho@hanyang.ac.kr
Received: 8 December 2016   • Revised: 22 February 2017   • Accepted: 31 March 2017
To evaluate the effect of intravitreal injection on the corneal endothelium according to the injected drug. METHODS: The present study included 118 eyes of 113 patients who received intravitreal injection. Before each injection and 1 month after the injection, specular microscopy was performed to evaluate the corneal endothelial changes and central corneal thickness. We classified the patients according to the injected drug (bevacizumab 21 eyes, ranibizumab 20 eyes, aflibercept 47 eyes, dexamathasone implant 30 eyes), phakic or pseudophakic eyes, single or multiple injections and analyzed them retrospectively. RESULTS: The mean corneal endothelial cell density was 2,693.2 ± 298.2 cells/mm² before injection and 2,686.8 ± 288.7 cells/mm² 1 month after injection, and there was no statistically significant difference (p = 0.731). According to the kind of drug, the mean corneal endothelial cell density and central corneal thickness were not significantly different before and 1 month after injection in any of the 4 groups. CONCLUSIONS: There were no significant changes in corneal endothelium before and 1 month after intravitreal injection of the various drugs.
Key Words: Corneal endothelium;Intravitreal injection;Specular microscopy

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