J Korean Ophthalmol Soc > Volume 57(2); 2016 > Article
Journal of the Korean Ophthalmological Society 2016;57(2):316-323.
DOI: https://doi.org/10.3341/jkos.2016.57.2.316    Published online February 1, 2016.
Safety and Efficacy of Intravitreal Ganciclovir Injections More than 10 Times for Cytomegalovirus Retinitis.
Kyu Hwan Jang, Jang Won Heo
1Department of Ophthalmology, Seoul National University Hospital, Seoul, Korea. hjw68@snu.ac.kr
2Department of Ophthalmology, Seoul National University College of Medicine, Seoul, Korea.
거대세포바이러스망막염에서 10회 이상 시행한 유리체강내 간시클로버 주입술의 효과와 안전성
장규환1⋅허장원1,2
서울대학교병원 안과1, 서울대학교 의과대학 안과학교실2
Abstract
PURPOSE
To study the treatment outcomes in patients who were administered multiple intravitreal ganciclovir injections more than 10 times alone without systemic anti-cytomegalovirus therapy for cytomegalovirus retinitis. CASE SUMMARY: A 64-year-old man who underwent immunosuppressive therapy after thymectomy due to an invasive thymoma and pure red-cell aplasia, a 60-year-old woman who underwent chemotherapy after diagnosis of diffuse large B-cell lymphoma, a 49-year-old man with a history of bone marrow transplantation due to acute myeloid leukemia, a 29-year-old woman with dermatomyositis treated with oral steroids and cyclosporine, and a 47-year-old woman who received intravitreal dexamethasone implant injections, intravitreal and subtenon steroid injections due to Behcet's disease were diagnosed with cytomegalovirus retinitis. All patients showed systemic complications such as pancytopenia after systemic anti-cytomegalovirus therapy, and therefore, they were administered multiple intravitreal ganciclovir injections alone. Best-corrected visual acuities improved in all patients, except in one case, where viral lesions were observed in the fovea. Retinal hemorrhaging and infiltrative lesions decreased in all patients. No severe complication was observed during the injection and in the follow-up period. CONCLUSIONS: Multiple intravitreal ganciclovir injections alone can be used as a treatment modality for cytomegalovirus retinitis to avoid the systemic side effects of systemic anti-cytomegalovirus therapy.
Key Words: Cytomegalovirus retinitis;Intravitreal ganciclovir injection;Multiple intravitreal ganciclovir injection


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