Journal of the Korean Ophthalmological Society 2007;48(1):63-74.
Published online January 31, 2007.
Epidemiologic and Clinical Characteristics of Polypoidal Choroidal Vasculopathy in Korean Patients.
Ji Woong Lee, In Taek Kim
Department of Ophthalmology, Kyungpook National University College of Medicine, Daegu, Korea. itkim@knu.ac.kr
한국인에 있어서 결절맥락막혈관병증의 역학과 임상소견
이지웅,김인택
Department of Ophthalmology, Kyungpook National University College of Medicine, Daegu, Korea
Correspondence:  Ji Woong Lee, M.D.
Abstract
PURPOSE
To investigate the incidence, demographic features and clinical characteristics of polypoidal choroidal vasculopathy (PCV) in Korean patients. METHODS: We retrospectively reviewed the medical records of 413 patients (485 eyes) diagnosed with choroidal neovascularization in exudative age-related macular degeneration between June 2001 and September 2005. All patients underwent complete ophthalmologic examination, fluorescein and indocyanine green angiography, and optical coherence tomography. RESULTS: Among a total of 485 eyes of 413 patients, 80 eyes of 66 patients (16.5%) were diagnosed with PCV. Men were predominantly affected (80.3%), and most patients were elderly with a mean age of 68.3 years (range, 50~93 years) and unilaterally involved (78.8%). The polypoidal lesions in PCV tended to be located in the macula area (62.5%). With respect to vascular network, fine vascular networks were observed in 51 eyes (63.7%) and large lesions were present in 16 eyes (20.0%). Clusters of grape-like polypoidal lesions (60%) were more common than solitary aneurysmal dilations (35.0%). Branching choroidal vessels were present in 67 eyes (83.7%) and absent in 13 eyes (16.3%). Optical coherence tomographic images of polypoidal lesions in 53 eyes showed uneven surfaces with more sharply peaked shapes different from those seen in the serous pigment epithelial detachment in age-related macular degeneration and central serous chorioretinopathy. CONCLUSIONS: The incidence of PCV in Korean patients was relatively high among various ethnic groups. Although the demographic and clinical features of PCV in Korea differed from Caucasian patients, they were similar to Japanese and Chinese patients.
Key Words: Cluster of grapes-like polypoidal lesion;Indocyanine green angiography;Optical coherence tomography;Polypoidal choroidal vasculopathy


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