The Effect of Bromocriptine on the Inhibition of Eyeball Growth at Various Concentration in Myopic Chicken Model.

Min, Byung Moo; Lee, Chang Ho; Lee, Yong Hee; Cha, Moo Byung; Hong, Sung Tae

Original Article

Journal of the Korean Ophthalmological Society 1996;37(12):2104-2110.
Published online December 1, 1996.

The Effect of Bromocriptine on the Inhibition of Eyeball Growth at Various Concentration in Myopic Chicken Model.

Byung Moo Min, Chang Ho Lee, Yong Hee Lee, Moo Byung Cha, Sung Tae Hong

¹Department of Ophthalmology, College of Medicine, Chungnam National University, Taejon, Korea.
²LG Chem Biotech Institute, Korea.

실험적으로 유발된 근시 병아리에서 BROMOCRIPTINE 의 농도에 따른 안구성장 억제효과

민병무(Byung Moo Min),이창호(Chang Ho Lee),이용희(Yong Hee Lee),차무병(Moo Byung Cha),홍성태(Sung Tae Hong)

Abstract

The authors examined the effect and concentration dependency of bromocriptine on the inhibition of axial length elongation in the experimentally induced myopic chicken. Two day-old white Leghorn chicken was monocularly deprived of form vision by lid suture. We measured the axial length of chicken's eye by ultrasonography at 2 day, 2 week, 4 week, and 6 week following repeated ophthalmic dosing beginning at 2 day. The first group was instilled with 0.1 cc of Tris buffer solution, whereas the second, third, and fourth groups were instilled with 0.1cc of 0.01 %, 0.02%, 0.04% bromocriptine solution respectively. All solutions were instilled twice daily for 6 weeks. In the inhibition of axial length elongation, the third group (0.02% bromocriptine) was most effective at 2 week (p<0.05), whereas the second group (0.01% bromocriptine) was most effective at 4 and 6 week (p<0.05). In summary, the axial length elongation of eyeball was effectively retarded by bromocriptine with the best efficacy at 0.02% in short-term dosing while at 0.01% in long-term dosing.

Key Words: Axial length;Bromocriptine;Myopic chicken eyeball