The Effect of Preoperative Subconjunctival Injection of Mitomycin C and Triamcinolone in Recurrent Pterygium.

Oh, Ji Hye; Kim, Hong Kyun

doi:2009.50.7.1005

J Korean Ophthalmol Soc > Volume 50(7); 2009 > Article

Original Article

Journal of the Korean Ophthalmological Society 2009;50(7):1005-1014.
DOI: https://doi.org/10.3341/jkos.2009.50.7.1005 Published online July 15, 2009.

The Effect of Preoperative Subconjunctival Injection of Mitomycin C and Triamcinolone in Recurrent Pterygium.

Ji Hye Oh, Hong Kyun Kim

Department of Ophthalmology, Kyungpook National University, School of Medicine, Daegu, Korea. okeye@hanmir.com

재발성 군날개 환자에서 수술 전 결막하 마이토마이신 및 트리암시놀론 주사의 효과

오지혜ㆍ김홍균

Department of Ophthalmology, Kyungpook National University, School of Medicine, Daegu, Korea

Abstract

PURPOSE
To evaluate the effect of a preoperative subconjunctival injection of mitomycin C or triamcinolone in patients with recurrent pterygium. METHODS: The records of 50 eyes of 50 patients who received excision of recurrent pterygium between June 2006 and January 2007 were reviewed. The recurrence rate and postoperative fibrovascular growth were compared in the preoperative subconjunctival mitomycin C, or triamcinolone injection group and non-treated control group. Additionally, the quantitative expression level of the transforming growth factor-beta1, -beta2 (TGF-beta1, -beta2), connective tissue growth factor (CTGF), and vascular endothelial growth factor (VEGF) in excised sample of the pterygium was assessed. RESULTS: There was no statistically significant difference in the recurrence rate and the relative gene expression level of growth factors in the triamcinolone group and the mitomycin group when compared with the non-treated control group. Postoperative fibrovascular proliferation was more severe in the triamcinolone group than other groups. CONCLUSIONS: Subconjunctival mitomycin C or triamcinolone as adjunctive therapy before pterygium excision did not influence the recurrence rate of pterygium.

Key Words: Adjunctive treatment;Pterygium;Mitomycin C;Subconjunctival injection;Triamcinolone