| Combination Therapy with Photodynamic Therapy and Intravitreal Bevacizumab in Idiopathic Macular Telangiectasia Type I. |
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In Geun Kim, Ji Eun Lee, Jung Min Park |
1Department of Ophthalmology, Maryknoll Medical Center, Busan, Korea. pjm1438@hanmail.net
2Department of Ophthalmology, Pusan National University Hospital, Pusan National University School of Medicine, Busan, Korea. |
| 광역학치료와 베바시주맙을 이용한 특발 중심와부근 모세혈관확장증 I형의 치료 |
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김인근1⋅이지은2⋅박정민1 |
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메리놀병원 안과1, 부산대학교 의학전문대학원 부산대학교병원 안과학교실2 |
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| Abstract |
PURPOSE
We investigated the clinical manifestations of combination therapy with photodynamic therapy (PDT) and intravitreal bevacizumab in idiopathic macular telangiectasia type I patients. METHODS: The present study included 7 patients who visited our clinic from May 2008 to February 2011 complaining of decreasing visual acuity and diagnosed as idiopathic macular telangiectasia type I including visible aneurysms at juxtafoveal area and telangiectatic vessels leakage based on fluorescein angiography. Additionally, all patients were treated with combination therapy with PDT and intravitreal bevacizumab. RESULTS: Visual acuity improved from 0.48 ± 0.14 (log MAR) to 0.18 ± 0.17 (log MAR) after the combination therapy, however, there was no change in intraocular pressure between before (17.9 ± 3.1) and after (16.8 ± 2.3) therapy. After combination therapy, fluorescein angiography showed decreased leakage of telangiectatic vessels and optical coherence tomography showed only minimal intraretinal edema. Central subfield macular thickness decreased from 301.9 ± 50.7 μm to 193.6 ± 58.8 μm after the combination therapy. CONCLUSIONS: Combination therapy with intravitreal bevacizumab injection and PDT in patients with idiopathic macular telangiectasia type I can result in a rapid decrease of macular edema, which can lead to rapid visual recovery. |
| Key Words:
Idiopathic macular telangiectasia type I;Intravitreal bevacizumab;Photodynamic therapy |
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