Bevacizumab Monotherapy Versus Combined Therapy with Photodynamic Therapy for Occult Choroidal Neovascularization in Age-Related Macular Degeneration.

Oh, Jong Hyun; Kim, Seong Woo; Oh, Jaeryung; Kwon, Soon Sun; Huh, Kuhl

doi:2013.54.10.1554

J Korean Ophthalmol Soc > Volume 54(10); 2013 > Article

Original Article

Journal of the Korean Ophthalmological Society 2013;54(10):1554-1560.
DOI: https://doi.org/10.3341/jkos.2013.54.10.1554 Published online October 15, 2013.

Bevacizumab Monotherapy Versus Combined Therapy with Photodynamic Therapy for Occult Choroidal Neovascularization in Age-Related Macular Degeneration.

Jong Hyun Oh, Seong Woo Kim, Jaeryung Oh, Soon Sun Kwon, Kuhl Huh

¹Department of Ophthalmology, Ilsan Hospital, Dongguk University, Goyang, Korea.
²Department of Ophthalmology, Korea University College of Medicine, Seoul, Korea. ksw64723@korea.ac.kr
³Department of Biostatistics, Korea University College of Medicine, Seoul, Korea.

잠복 맥락막신생혈관을 동반한 나이관련황반변성에서 베바시주맙 단독치료와 광역학요법 병합치료

오종현¹⋅김성우²⋅오재령²⋅권순선³⋅허 걸²

Department of Ophthalmology, Ilsan Hospital, Dongguk University¹, Goyang, Korea
Department of Ophthalmology, Korea University College of Medicine², Seoul, Korea
Department of Biostatistics, Korea University College of Medicine³, Seoul, Korea

Abstract

PURPOSE
To compare clinical outcomes between intravitreal bevacizumab (IVB) monotherapy and combined therapy with half-fluence rate verteporfin photodynamic therapy (PDT) for occult choroidal neovascularization (CNV) secondary to age-related macular degeneration (AMD). METHODS: Medical records were reviewed in consecutive patients who underwent IVB monotherapy or combined therapy with PDT for occult CNV secondary to AMD and had a 12-month follow-up period. After 3 consecutive monthly IVB injections, both groups were eligible for additional IVB injections when necessary. Best-corrected visual acuity (BCVA), central macular thickness (CMT), and number of additional IVB injections were compared between the groups. RESULTS: Thirty-nine eyes underwent IVB monotherapy (IVB group) and 25 eyes underwent combined therapy (PDT+IVB group). Mean BCVA improved significantly in the PDT+IVB group (p = 0.046) and not in IVB group (p = 0.213). A significant reduction in mean CMT occurred in both groups (p < 0.001). The mean number of additional IVB injections was 1.6 +/- 1.33 in the IVB group and 0.5 +/- 1.01 in the PDT+IVB group (p = 0.001). There were no serious complications. CONCLUSIONS: Combined therapy with half-fluence rate PDT improved BCVA and reduced the number of additional IVB injections in the eyes with occult CNV secondary to AMD.

Key Words: Age-related macular degeneration;Bevacizumab;Occult choroidal neovascularization;Photodynamic therapy