| Additional Retrobulbar Triamcinolone Acetonide Injection for Retrobulbar Optic Neuritis Patients. |
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Joon Ho Park, Jae Pil Shin, Bo Young Chun |
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Department of Ophthalmology, Kyungpook National University School of Medicine, Daegu, Korea. byjun424@hotmail.com |
| 고용량 스테로이드 치료에 추가 트리암시놀론 구후주사가 구후시신경염의 시력회복에 미치는 영향 |
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박준호⋅신재필⋅전보영 |
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Department of Ophthalmology, Kyungpook National University School of Medicine, Daegu, Korea |
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| Abstract |
PURPOSE
To evaluate the effect of additional retrobulbar triamcinolone acetonide (TA) injection on early recovery of visual acuity in retrobulbar optic neuritis patients. METHODS: A prospective, randomized clinical study including 30 patients with retrobulbar optic neuritis was conducted between March 2003 and June 2007. Patients were divided into 2 groups: Group 1 (n = 9) with retrobulbar triamcinolone (TA, 40 mg/1 ml) injection on the first day of ONTT protocol, and group 2 (n = 21) with conventional ONTT protocol. The following parameters were measured and analyzed: patient's sex, age, pupillary reactions, color vision, visual field, and best-corrected visual acuity before treatment, and after 1 day, 1 week, 2 weeks, 1 month, and 3 months of follow-up. RESULTS: Mean visual acuity before treatment was 1.00 +/- 0.89 log MAR units in group 1 and 0.98 +/- 0.75 log MAR units in group 2. One day after injection, visual acuity was better in group 1 (0.50 +/- 0.42 log MAR units) than in group 2 (0.73 +/- 0.61 log MAR units), however, there was no statistically significant difference between the 2 groups (p = 0.07). There was no significant difference in visual acuity, recovery of RAPD, color vision, or visual field at 3 months of follow-up. No serious side effect related to retrobulbar TA injection was observed. CONCLUSIONS: Additional retrobulbar TA injection may help optic neuritis patients who have a need for prompt visual recovery. However, further studies are required to ascertain whether this procedure can help early recovery of visual acuity in retrobulbar optic neuritis patients. |
| Key Words:
Best corrected visual acuity;Retrobulbar optic neuritis;Retrobulbar triamcinolone acetonide injection |
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