Posterior Sub-Tenon Triamcinolone Acetonide Injection for Recurrent Diabetic Macular Edema after Repeated Intravitreal Bevacizumab Injections.

Kim, Jong Ho; Park, Dong Ho; Shin, Jae Pil; Kim, Si Yeol

doi:2011.52.9.1063

J Korean Ophthalmol Soc > Volume 52(9); 2011 > Article

Original Article

Journal of the Korean Ophthalmological Society 2011;52(9):1063-1070.
DOI: https://doi.org/10.3341/jkos.2011.52.9.1063 Published online September 15, 2011.

Posterior Sub-Tenon Triamcinolone Acetonide Injection for Recurrent Diabetic Macular Edema after Repeated Intravitreal Bevacizumab Injections.

Jong Ho Kim, Dong Ho Park, Jae Pil Shin, Si Yeol Kim

¹Department of Ophthalmology, Kyungpook National University School of Medicine, Daegu, Korea.
²Nune Eye Hospital, Daegu, Korea. kimsy@knu.ac.kr

반복된 유리체강내 베바시주맙 주입술 후 재발한 당뇨황반부종에 후테논낭하 트리암시놀론 주입술

김종호¹⋅박동호¹⋅신재필¹⋅김시열²

Department of Ophthalmology, Kyungpook National University School of Medicine¹, Daegu, Korea Nune Eye Hospital², Daegu, Korea

Abstract

PURPOSE
To evaluate posterior sub-Tenon injection of triamcinolone acetonide (TA) for recurrent diabetic macular edema (DME) after repeated intravitreal bevacizumab (IVB). METHODS: This is a retrospective interventional case series comprised of 35 eyes (32 patients) with recurrent clinically significant DME after two or more IVB treatments. All patients were administered TA 40 mg injections. Best-corrected visual acuity (BCVA), central macular thickness (CMT), and intraocular pressure (IOP) were reevaluated at months 1, 3, and 6. RESULTS: The baseline OCT showed five eyes with diffuse retinal thickening, 18 eyes with cystoid macular edema, and 12 eyes with serous retinal detachment. Mean BCVA improved at months 1 and 3, and mean CMT decreased at months 1 and 3. However, mean BCVA and CMT at six months was not different from baseline. Each DME pattern showed significant improvements in BCVA and CMT at three months. Mean IOP at months 1, 3, and 6 did not show any significant difference from baseline. No eyes showed complications including cataract progression or endophthalmitis. CONCLUSIONS: Posterior sub-Tenon injection of TA should be considered for patients with recurrent DME after repeated IVB. The studied eyes showed improvements in BCVA and CMT during three months in all of the three patterns of DME.

Key Words: Bevacizumab;Diabetic macular edema;Posterior sub-Tenon injection;Triamcinolone acetonide