Combined Anti-VEGF and C3F8 Injection for Large Submacular Hemorrhage Secondary to Age-Related Macular Degeneration.

Lee, Min Young; Seo, Won Moon; Choi, Yul Je

doi:2013.54.3.443

J Korean Ophthalmol Soc > Volume 54(3); 2013 > Article

Original Article

Journal of the Korean Ophthalmological Society 2013;54(3):443-448.
DOI: https://doi.org/10.3341/jkos.2013.54.3.443 Published online March 15, 2013.

Combined Anti-VEGF and C3F8 Injection for Large Submacular Hemorrhage Secondary to Age-Related Macular Degeneration.

Min Young Lee, Won Moon Seo, Yul Je Choi

¹Department of Ophthalmology, Dongkang Medical Center, Ulsan, Korea. mdseowm@msn.com
²Myung Eye Clinic, Ulsan, Korea.

나이관련황반변성의 심한 황반하출혈에서 유리체강내 팽창가스와 항혈관내피성장인자 병합요법

이민영¹⋅서원문¹⋅최율제²

Department of Ophthalmology, Dongkang Medical Center¹, Ulsan, Korea
Myung Eye Clinic², Ulsan, Korea

Abstract

PURPOSE
To evaluate the effect of intravitreal expansile gas (C3F8) with anti-VEGF injection for the treatment of large submacular hemorrhage (SMH) secondary to age-related macular degeneration (ARMD). METHODS: In this report, 18 eyes of 18 patients with large SMH secondary to ARMD were treated with a simultaneous injection of 0.3 cc C3F8 and 0.05 ml anti-VEGF intravitrealy. RESULTS: The mean age was 64.89 +/- 5.68 years and the mean size of SMH was 4.44 +/- 1.25 disc diameters (DD). The minimum follow-up period was 12 months (range: 12-17 months). Mean preoperative best corrected visual acuity (BCVA) was 1.72 +/- 0.56 log MAR which improved significantly to 1.01 +/- 0.68 log MAR at 12 months (p = 0.002). SMH displacement occurred in all eyes. BCVA improved 2 or more lines in 11 eyes (61.1%) and deteriorated in 1 eye (5.6%). CONCLUSIONS: In this report, intravitreal injection of an expansible gas (C3F8) with anti-VEGF produced successful results in anatomical displacement of SMH and early visual improvement.

Key Words: Age-related macular degeneration;Anti-VEGF;C3F8 gas;Submacular hemorrhage