| Effect of Bevacizumab on Survival and Production of Nitric Oxide in Trabecular Meshwork Cells. |
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Sin Hoo Kim, Jae Woo Kim |
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Department of Ophthalmology, Catholic University of Daegu College of Medicine, Daegu, Korea. jwkim@cu.ac.kr |
| 베바시주맙이 섬유주세포의 생존과 일산화질소의 생성에 미치는 영향 |
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김신후ㆍ김재우 |
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Department of Ophthalmology, Catholic University of Daegu College of Medicine, Daegu, Korea |
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| Abstract |
PURPOSE
To investigate the effect of bevacizumab, a monoclonal antibody against vascular endothelial growth factor (VEGF), on the survival and production of nitric oxide (NO) in human trabecular meshwork cells (HTMC). METHODS: Primarily cultured HTMC were exposed to 0, 0.25, 1.0, and 2.5 mg/ml bevacizumab for 24 hours. Cellular survival and production of NO were assessed by MTT assay and Griess assay, respectively. RESULTS: Bevacizumab did not affect the cellular survival at low concentrations but decreased cellular survival significantly at high concentrations (>1.0 mg/ml) accompanied with increased NO production. CONCLUSIONS: High concentrations of bevacizumab may be toxic to HTMC. |
| Key Words:
Bevacizumab;Nitric oxide;Trabecular meshwork cells |
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