Journal of the Korean Ophthalmological Society 2006;47(5):834-842.
Published online May 31, 2006.
Effects of Varying the Mitomycin C Subconjunctival Injection Time in Glaucoma Filtration Surgery in Rabbits.
Weon Seon Jung, Seung Youn Jea, Sung Who Park, Jin Young Kim, Sang Hyup Lee
1Bombit Eye Clinic, Busan, Korea.
2Department of Ophthalmology, College of Medicine, Busan National University, Busan, Korea.
3Classic Eye Clinic, Busan, Korea.
녹내장 여과수술에서의 마이토마이신 결막하 주사 시기에 따른 여과포 형성의 실험적 연구
Bombit Eye Clinic1, Busan, Korea Department of Ophthalmology, College of Medicine, Busan National University2, Busan, Korea Classic Eye Clinic3, Busan, Korea
Correspondence:  Weon Seon Jung, M.D.1
To investigate the effects of varying the time of Mitomycin-C (MMC) subconjunctival injection before, during and after operation. METHOD: We divided rabbits into 3 groups according to injection time. Subconjunctival injections of 0.01% MMC 0.05 ml were given to the preoperative group at 6, 12 and 24 hours before operation, and to the postoperative group at 6, 12 and 24 hours after operation. The control group was given the injections during operation. Bleb formation and histologic analyses were studied for 4 weeks after operation. RESULTS For gross findings, the blebs of the preoperative and control groups were seen on the fourth day and completely formed at one week after operation, and were larger than those of the postoperative group. On the other hand, the blebs of the postoperative group were seen to have poor formation, displaying hypervascularity on the fourth day and disappearing one week after operation. For histologic findings, the proliferation of collagen fibers and the undifferentiation of fibroblasts observed in the preoperative and control groups were almost identical. But, the proliferation of collagen fibers and well-differentiated fibroblasts were seen to increase in the postoperative group, so aqueous flow was obstructed at week 3. CONCLUSIONS: Subconjunctival injections within 24 hours before or during glaucoma filtration surgery were better for bleb formation and preservation than those administerd after surgery.
Key Words: Bleb;Mitomycin C;Subconjunctival injection

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