| Animal Study of Photodynamic Therapy with Verteporfin in Corneal Neovascularization. |
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Hyeon Ju Nah, Kyung Chul Yoon, Wook Bin Im, Kyu Youn Ahn, Man Seong Seo |
1Department of Nursing, Dongkang College, Gwangju, Korea.
2Department of Ophthalmology, Chonnam National University Medical School, Gwangju, Korea. msseo@chonnam.ac.kr
3School of Biological Science and Technology, Chonnam National University, Gwangju, Korea.
4Department of Anatomy, Chonnam National University Medical School, Gwangju, Korea. |
| 각막신생혈관에 대한 버테포르핀을 이용한 광역학치료의 동물실험 |
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나현주1,윤경철2,임욱빈3,안규윤4,서만성2 |
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Department of Nursing, Dongkang College1, Gwangju, Korea, Department of Ophthalmology, Chonnam National University Medical School2, Gwangju, Korea, School of Biological Science & Technology, Chonnam National University3, Gwangju, Korea, Department of Anatomy, Chonnam National University Medical School4, Gwangju, Korea |
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Correspondence:
Hyeon-Ju Nah, M.N.1 |
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| Abstract |
PURPOSE
To determine the efficacy of photodynamic therapy (PDT) with verteporfin (Visudyne(R), Norvatis Ophthalmics AG, Hettingen, Switzerland), a benzoporphyrin derivative, in the treatment of corneal neo-vascularization (CN) in a rabbit eye model. METHODS: CN was induced by placing instrastromal sutures in the cornea. Two weeks after suturing, verteporfin was administrated intravenously and 1 hour later, the right eye (treated group) was exposed to a laser with a 689 nm wavelength, and the left eye was used as the control. The changes in CN were analyzed using biomicroscopy and optical microscopy in twelve rabbits. RESULTS: The mean percentages of the neovascular area in the control and treated groups were 96.4 +/- 1.9% and 90.3 +/- 3.5% (P=0.009) at three days after the PDT, 88.6 +/- 4.6% and 71.6 +/- 6.2% (P<0.001) at one week, and 76.8 +/- 4.4% and 43.6 +/- 15.1% (P<0.001) at two weeks, respectively. Optical microscopy showed significant differences between the control and treated group in terms of the area and number of CN (P<0.05). CONCLUSIONS: PDT with verteporfin is a safe and effective procedure for regressing CN. However, a further study will be necessary. |
| Key Words:
Corneal neovascularization;Photodynamic therapy;Verteporfin |
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