Botulinum Toxin A Chemodenervation in Strabismus.

Lee, Sung Ho; Han, Sueng Han; Lee, Jong Bok

Original Article

Journal of the Korean Ophthalmological Society 2003;44(7):1592-1599.
Published online July 1, 2003.

Botulinum Toxin A Chemodenervation in Strabismus.

Sung Ho Lee, Sueng Han Han, Jong Bok Lee

The Institute of Vision Research, Department of Ophthalmology, Yonsei University College of Medicine, Seoul, Korea. shhan222@yumc.yonsei.ac.kr

한국인 사시환자에서 보툴리눔 A 독소 화학절단술의 임상적 고찰

이성호 ( Sung Ho Lee ) , 한승한 ( Sueng Han Han ) , 이종복 ( Jong Bok Lee )

Abstract

PURPOSE
We investigated the therapeutic effect of botulinum toxin chemodenervation for the treatment of Korean strabismus patients. METHODS: From February 1996 to November 2001, 52 patients with various strabismus were treated with botulinum toxin chemodenervation and followed up for more than 6 months. There were 15 acute paralytic strabismus, 14 chronic paralytic strabismus (more than 6 months), 13 sensory strabismus, 5 consecutive strabismus, 3 residual strabismus and 2 comitant strabismus. We reviewed the final angle of deviation and complications. RESULTS: There were 29 men and 23 women with the mean age of 38.8+/-12.1 years. The mean follow up period was 8.08+/-2.27 months. The mean deviation before and after chemodenervation were 32.6+/-16.0 PD and 12.9+/-16.0 PD and improving rate of the strabismus angle was 60.4%. The final deviation of 36 patients (69.2%) were within 10 PD. Hypertropia occurred in 10 patients (19.2%), ptosis in 9 patients (17.3%), and subconjuntival hemorrhage in 2 patients (3.8%). CONCLUSION: Botulinum toxin chemodenervation is thought to have good therapeutic effects in acute paralytic strabismus as well as in chronic paralytic strabismus and other strabismus. The complications were relatively temporary and insignificant, so it is thought to be a safe method of strabismus treatment.

Key Words: Botulinum toxin;Chemodenervation;Strabismus