Influence of Botulinum Toxin A on Corneal Astigmatism.

Song, Young Soo; Moon, Nam Ju

Original Article

Journal of the Korean Ophthalmological Society 2004;45(10):1708-1712.
Published online October 1, 2004.

Influence of Botulinum Toxin A on Corneal Astigmatism.

Young Soo Song, Nam Ju Moon

Department of Ophthalmology, College of Medicine, Chung-Ang University, Seoul, Korea. njmoon@chol.com

각막난시에 미치는 보툴리눔 독소 A의 영향

송영수 ( Young Soo Song ) , 문남주 ( Nam Ju Moon )

Abstract

PURPOSE
This study was conducted to determine if there is a corneal astigmatic change in patients with strong lid tension, such as essential blepharospasm. METHODS: Twenty-two eyes of 14 patients with blepharospasm who had undergone botulinum toxin A (Botox(R), Allergan) injection during the period February 2001 through January 2002 were included. The corneal astigmatic change was evaluated before injection and after 1st month and 6th month of injection by keratometric measurements. Corneal astigmatism was measured before and 1month after botulinum toxin A injection and changes of corneal astigmatism were checked using vector methods (corneal astigmatism change vector). RESULTS: The with-the-rule astigmatism group showed decreased average corneal astigmatism while the against-the-rule group showed increased astigmatism at 1month after injection. The corneal astigmatic change vector showed significantly greater against-the-rule change (16 eyes) than with-the-rule change (6 eyes) at 1 month after injection. CONCLUSIONS: We found that the corneal astigmatism was influenced by botulinum toxin A injection in patients with essential blepharospasm who seemed to have strong lid tension. Therefore it was proved that the corneal astigmatism was influenced by lid tension.

Key Words: Botulinum toxin A;Corneal astigmatism;Lid tension