Journal of the Korean Ophthalmological Society 2002;43(9):1670-1678.
Published online September 1, 2002.
Brimonidine 0.2% versus Apraclonidine 0.5% for Controlling Intraocular Pressure Elevation after Q-switched Nd:YAG Laser Posterior Capsulotomy.
Seong Lyong Jeon, Ju Yeon Lee, Kyung Wha Lee
Department of Ophthalmology, Hangang Sacred Heart Hospital, The Hallym University Medical College, Seoul, Korea.
야그레이저 후낭절개술시 안압상승에 대한 0.2% Brimonidine 과 0.5% Apraclonidine 의 효과 비교
전성룡 ( Seong Lyong Jeon ) , 이주연 ( Ju Yeon Lee ) , 이경화 ( Kyung Wha Lee )
To compare the effectiveness of 0.2% brimonidine tartrate and that of 0.5% apraclonidine hydrochloride for controlling IOP elevation after Nd:YAG laser capsulotomy. METHODS: Thirty eyes were given with 0.2% brimonidine (group 1) and fourteen eyes with 0.5% apraclonidine (group 2) before and after the procedure. Fifteen eyes served as untreated controls (group 3). Intraocular pressure and visual acuity were measured preoperatively and 1 hour, 3 hours, 24 hours, and 1 week postoperatively in all cases. RESULTS: The postoperative mean intraocular pressures of group 3 (14.97+/-3.58, 16.47+/-3.93 mmHg) at 1 hour and 3 hours were statistically significant higher than those of group 1 (11.23+/-3.43, 11.50+/-3.01mmHg), and those of group 2 (10.79+/-3.51, 11.57+/-3.03 mmHg)(p< 0.05), but, there were no statistically significant differences in mean IOP at 1 hour and 3 hours between group 1 and group 2 (P=0.569, P=0.610). At 1 hour and 3 hours, there was no case of IOP elevation of 5 mmHg above baseline in group1 and group 2. but, there were 5 cases (33.3%) at 1 hour and 6 cases (40%) at 3 hours in group 3. CONCLUSIONS: This result suggests that 0.2% brimonidine and 0.5% apraclonidine are equally effective for preventing acute IOP elevation after Nd:YAG laser capsulotomy, that is, 0.2% brimonidine is an effective and well-tolerated agent for preventing acute IOP rises after Nd:YAG laser posterior capsulotomy.
Key Words: Apraclonidine hydrochloride 0.5%;Brimonidine tartrate 0.2%;IOP elevation;Nd:YAG laser posterior capsulotomy

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