Journal of the Korean Ophthalmological Society 2002;43(9):1670-1678.
Published online September 1, 2002.
Brimonidine 0.2% versus Apraclonidine 0.5% for Controlling Intraocular Pressure Elevation after Q-switched Nd:YAG Laser Posterior Capsulotomy.
Seong Lyong Jeon, Ju Yeon Lee, Kyung Wha Lee
Department of Ophthalmology, Hangang Sacred Heart Hospital, The Hallym University Medical College, Seoul, Korea. kyungwlee@hanmail.net
야그레이저 후낭절개술시 안압상승에 대한 0.2% Brimonidine 과 0.5% Apraclonidine 의 효과 비교
전성룡 ( Seong Lyong Jeon ) , 이주연 ( Ju Yeon Lee ) , 이경화 ( Kyung Wha Lee )
Abstract
PURPOSE
To compare the effectiveness of 0.2% brimonidine tartrate and that of 0.5% apraclonidine hydrochloride for controlling IOP elevation after Nd:YAG laser capsulotomy. METHODS: Thirty eyes were given with 0.2% brimonidine (group 1) and fourteen eyes with 0.5% apraclonidine (group 2) before and after the procedure. Fifteen eyes served as untreated controls (group 3). Intraocular pressure and visual acuity were measured preoperatively and 1 hour, 3 hours, 24 hours, and 1 week postoperatively in all cases. RESULTS: The postoperative mean intraocular pressures of group 3 (14.97+/-3.58, 16.47+/-3.93 mmHg) at 1 hour and 3 hours were statistically significant higher than those of group 1 (11.23+/-3.43, 11.50+/-3.01mmHg), and those of group 2 (10.79+/-3.51, 11.57+/-3.03 mmHg)(p< 0.05), but, there were no statistically significant differences in mean IOP at 1 hour and 3 hours between group 1 and group 2 (P=0.569, P=0.610). At 1 hour and 3 hours, there was no case of IOP elevation of 5 mmHg above baseline in group1 and group 2. but, there were 5 cases (33.3%) at 1 hour and 6 cases (40%) at 3 hours in group 3. CONCLUSIONS: This result suggests that 0.2% brimonidine and 0.5% apraclonidine are equally effective for preventing acute IOP elevation after Nd:YAG laser capsulotomy, that is, 0.2% brimonidine is an effective and well-tolerated agent for preventing acute IOP rises after Nd:YAG laser posterior capsulotomy.
Key Words: Apraclonidine hydrochloride 0.5%;Brimonidine tartrate 0.2%;IOP elevation;Nd:YAG laser posterior capsulotomy


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