The Effect of Ophthalmic Solution and Ointment on Healing of Experimental Wound of Rabbit Corneal Epithelium.

Chang, Bong Leen; Choi, Kwang Woo

Original Article

Journal of the Korean Ophthalmological Society 1975;16(3):198-200.
Published online March 1, 1975.

The Effect of Ophthalmic Solution and Ointment on Healing of Experimental Wound of Rabbit Corneal Epithelium.

Bong Leen Chang, Kwang Woo Choi

Department of Ophthalmology, College of Medicine, Seoul National University, Korea.

연고제와 용액이 토끼 각막상피 치유에 미치는 영향

장봉린 , 최광우 ( Bong Leen Chagn , Kwang Woo Choi )

Abstract

The effect of 1% atropine solution and 1% atropine ointment on healing of corneal epithelium in 20 rabbits was studied. Corneal epithelium was removed by #15 blade in central area of 7mm in diameter under topical anesthesia with 0.5% pontocaine. 1% atropine solution was applied three times daily to Rt. eyes, and 1% atropine ointment to Lt. eyes. Progress of epithelial healing was observed by fluorescent staining of the wound. At the end of 24 hours, fluorescent staining area was 46.90% in average for Rt. eyes, and 51.90% in average for Lt. eyes. At the end of 48 hours, it was 7.83% for Rt. eyes, and 11.0% for Lt. eyes. At the end of 72 hours, All of Rt. eyes did not stain, but 2 of 10 Lt. eyes were faintly stained. Difference between ophthalmic solution and ointment on the effect of corneal epithelial healing was not significant.