The Effect of Indomethacin Pretreatment Before Nd:YAG Laser Anterior Capsulotomy on Intraoular Pressure of Rabbits.

Myong, Yoon Won; Baek, Nam Ho; Rhee, Sang Wook

Original Article

Journal of the Korean Ophthalmological Society 1993;34(5):408-417.
Published online May 1, 1993.

The Effect of Indomethacin Pretreatment Before Nd:YAG Laser Anterior Capsulotomy on Intraoular Pressure of Rabbits.

Yoon Won Myong, Nam Ho Baek, Sang Wook Rhee

Department of Ophthalmology, St. Mary's Hospital, Catholic University Medical College, Seoul, Korea.

가토에서 Nd : YAG 레이저로 수정체전낭절개술시 Indomethacin 의 전처치가 안압에 미치는 영향

백남호(Nam Ho Baek),이상욱(Sang Wook Rhee),명윤원(Yoon Won Myong)

Abstract

To evaluate the cause of intraocular pressure elevation and the effect of indomethacin after Nd:YAG laser anterior capsulotomy in rabbit authors measured the intraocular pressure, prostaglandin E2 and thromboxane B2 concentrations of aquous humor, and observed the morphological change of trabecular meshwork using scanning electron microscope in indomethacin pretreatment (group I) and non-treatment (group II) group. The intraocular pressure and the concentrations of prostaglanding E2 and thromboxane B2 in group II were higher than in group I. And the scanning electron microscopy showed inflammatory reaction in group II. These results support that the causes of intraocular pressure elevation are elevation of prostaglandin E2. thromboxane B2 concentrations in aqueous humor and intraocular inflammation secondary to it.

Key Words: Indomethacin;Intraocular pressure;Nd:YAG laser anterior capsulotomy;Prostaglandin E2;Thromboxane B2