The Effect of Topical Antibiotics on the Experimental Pseudomonas Keratitis.

Koh, Hyoung Jun; Kim, Hong Bok

Original Article

Journal of the Korean Ophthalmological Society 1992;33(4):310-319.
Published online April 1, 1992.

The Effect of Topical Antibiotics on the Experimental Pseudomonas Keratitis.

Hyoung Jun Koh, Hong Bok Kim

Department of Ophthalmology, College of Medicine, Yonsei University Seoul, Korea.

실험적 녹농균성 각막염에 대한 국내 시판 점안 항생제의 치료 효과

고형준(Hyoung Jun Koh),김홍복(Hong Bok Kim)

Abstract

Recently, acute pseudomonas keratitis is reported to occur more frequently. If treatment is not adequate after the invasion of Pseudomonas into the cornea, corneal perforation ensues within 48 hours. Hence the rapid diagnosis and treatment is required, and the treatment mostly depends on the antibiotics. Pseudomonas keratitis induced in the rabbit cornea by inoculating Pseudomonas aeruginosa (lID 1210). Then the keratitis was treated with topical antibiotics available in Korea Chloramphenicol(R), Polyspectran(R), Tobra(R), Gentamicin(R), Tarivid(R). The effect of the antibiotics on Pseudomonas keratitis was evaluated clinically as well as bacteriologically and irritation of the antibiotics against the eye was also obsesved. 1. Polyspectran(R), tobra(R), gentamicin(R), tarivid(R) treated experimental Pseudomonas keratitis in the rabbit eyes but chloramphenicol(R) and saline did not inhibit the bacterial growth of the rabbit corneas. 2. Against the rabbit eyes, chloramphenicol(R) and polyspectran(R) were the most irritable aptibiotics, where as Gentamicin(R) and tarivid(R) were the moderate, and tobra(R) and saline were the least in the extent of irritation.

Key Words: Pseudomonas keratitis;Topical antibiotics