J Korean Ophthalmol Soc > Volume 59(6); 2018 > Article
Journal of the Korean Ophthalmological Society 2018;59(6):527-536.
DOI: https://doi.org/10.3341/jkos.2018.59.6.527    Published online June 15, 2018.
The Relationships of Intraocular Pressure, Cerebrospinal Fluid Pressure, and Trans-lamina Cribrosa Pressure Differences with Myopia.
Seung Kwan Nah, Young Hoon Ohn, Chan Yun Kim, Si Hyung Lee
1Department of Ophthalmology, Bucheon Hospital, Soonchunhyang University College of Medicine, Bucheon, Korea. sieh12@schmc.ac.kr
2The Institute of Vision Research, Department of Ophthalmology, Yonsei University College of Medicine, Seoul, Korea.
근시의 정도에 따른 안압, 뇌척수압 및 사상판경유압력차의 관계
순천향대학교 의과대학 부천병원 안과학교실1, 연세대학교 의과대학 안과학교실 시기능개발연구소2
Correspondence:  Si Hyung Lee,
Email: sieh12@schmc.ac.kr
Received: 23 November 2017   • Revised: 28 February 2018   • Accepted: 4 June 2018
To investigate the relationships between myopia and the three parameters of intraocular pressure (IOP), estimated cerebrospinal fluid pressure (CSFP), and the trans-lamina cribrosa pressure difference (TLCPD). METHODS: A total of 6,933 adults (≥19 years of age) who participated in the Korea National Health and Nutrition Examination Survey (2008–2012). These subjects were divided into two groups: young age group (19–49 years of age) and old age group (≥50 years of age). The estimated CSFP was calculated as CSFP (mmHg) = 0.44 body mass index (kg/m2) + 0.16 diastolic blood pressure (mmHg) − 0.18 age (years) − 1.91. The TLCPD was calculated by subtracting the CSFP from the IOP. RESULTS: The mean estimated CSFP in the total population was 13.7 ± 0.1 mmHg (young, 14.2 ± 0.1 mmHg; old, 11.5 ± 0.1; p < 0.01), the mean IOP in the total population was 14.0 ± 0.1 mmHg (young, 14.0 ± 0.1 mmHg; old, 14.1 ± 0.1; p = 0.724), and the mean TLCPD in the total population was 0.7 ± 0.1 mmHg (young, 0.3 ± 0.1 mmHg; old, 3.0 ± 0.2; p < 0.001). After adjusting for confounding factors, multivariate linear regression analyses revealed significant positive associations between the degree of myopia and the estimated CSFP (p < 0.001; β, 0.12; spherical equivalent [SE], 0.03), as well as IOP (p < 0.001; β, 0.29; SE, 0.05). As a result, a higher TLCPD also showed a significant association with more myopic refractive error (p=0.002; β, 0.18; SE, 0.06). In subgroup analyses, a similar association was shown only in the young age group (estimated CSFP, p < 0.001; β, 0.12; SE, 0.03; IOP, p < 0.001; β, 0.28; SE, 0.05; TLCPD, p = 0.005; β, 0.17; SE: 0.06), while the old age group did not show a significant association between TLCPD and the degree of myopia (p = 0.274; β, 0.18; SE, 0.16). CONCLUSIONS: The calculated TLCPD showed an association with high myopia. It was consistent with the potential role of high myopia in the pathogenesis of open-angle glaucoma.
Key Words: Cerebrospinal fluid pressure;Intraocular pressure;Myopia;Open-angle glaucoma

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