J Korean Ophthalmol Soc > Volume 59(9); 2018 > Article
Journal of the Korean Ophthalmological Society 2018;59(9):861-866.
DOI: https://doi.org/10.3341/jkos.2018.59.9.861    Published online September 15, 2018.
Poorly Differentiated Neuroendocrine Carcinoma of the Eyelid.
Kyuyeon Cho, Jeong Hee Kim, Dong Cheol Lee, Yeon Lim Suh, Kyung In Woo, Yoon Duck Kim
1Department of Ophthalmology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea. ydkimoph@skku.edu
2Department of Pathology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.
눈꺼풀에 발생한 저분화 신경내분비암 1예
성균관대학교 의과대학 삼성서울병원 안과학교실1, 성균관대학교 의과대학 삼성서울병원 병리학교실2
Correspondence:  Yoon-Duck Kim
Email: ydkimoph@skku.edu
Received: 29 March 2018   • Revised: 13 June 2018   • Accepted: 26 August 2018
To report a case of poorly differentiated neuroendocrine carcinoma of the eyelid. CASE SUMMARY: A 70-year-old male presented with a 5-month history of a right upper eyelid mass. The mass appeared as 1.2 × 1.2 cm on the right upper eyelid. A mass excision was performed under frozen section control. The tumor was completely excised with a safety margin clearance and an upper eyelid reconstruction was performed. Histopathological examination revealed a tumor composed of small atypical cells which showed a high nuclear/cytoplasm ratio, nuclear molding, and increased mitotic activity. Immunohistochemical examination revealed positive reactivity for Ki-67, synaptophysin, CD56, and negative reactivity for chromogranin, cytokeratin 20, and thyroid transcription factor-1. CONCLUSIONS: Primary neuroendocrine carcinoma of the eyelid is extremely rare, but the tumor has high malignancy and readily metastasizes. Poorly differentiated neuroendocrine carcinoma should be considered in the differential diagnosis of a rapidly growing eyelid mass.
Key Words: Eyelid;Merkel cell carcinoma;Poorly differentiated neuroendocrine carcinoma;Small cell carcinoma;Small cell neuroendocrine carcinoma

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