J Korean Ophthalmol Soc > Volume 59(10); 2018 > Article
Journal of the Korean Ophthalmological Society 2018;59(10):984-988.
DOI: https://doi.org/10.3341/jkos.2018.59.10.984    Published online October 15, 2018.
Rapid Progression of the Epiretinal Membrane after Intravitreal Aflibercept Injection.
Ji Min Kwon, Myung Shin Lee, Kang Yeun Pak, Hyun Woong Kim
Department of Ophthalmology, Haeundae Paik Hospital, Inje University College of Medicine, Busan, Korea. maekbak@gmail.com
유리체강 내 애플리버셉트 주사 후 급격히 진행한 망막앞막
인제대학교 의과대학 해운대백병원 안과학교실
Correspondence:  Hyun Woong Kim,
Email: maekbak@gmail.com
Received: 8 May 2018   • Revised: 3 July 2018   • Accepted: 27 September 2018
To report a case of rapid progression of the epiretinal membrane following intravitreal aflibercept injection in a patient with exudative age-related macular degeneration. CASE SUMMARY: An 82-year-old female presented with a complaint of decreased visual acuity in her left eye for 1 month. The initial best-corrected visual acuity was 0.2 in the left eye. Fundus examination and optical coherence tomography revealed soft drusen with retinal hemorrhage of the macula and a transparent epiretinal membrane in the left eye. Fluorescein angiography and indocyanine green angiography showed retinal angiomatous proliferation (RAP) of the left eye, so intravitreal aflibercept injection was performed. One month after the first injection, intraretinal cystic macular edema decreased, while transparency of the epiretinal membrane decreased and reflectivity and thickness of the membrane increased. After two additional injections of aflibercept, RAP showed improvement, whereas the epiretinal membrane progressed. Visual acuity of the left eye decreased to 0.1 and vitrectomy of the membrane was performed. CONCLUSIONS: Careful observation for potentially rapid progression of epiretinal membrane is needed after intravitreal aflibercept injection in the management of exudate age-related macular degeneration accompanied by epiretinal membrane.
Key Words: Aflibercept;Age-related macular degeneration;Epiretinal membrane

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