J Korean Ophthalmol Soc > Volume 60(6); 2019 > Article
Journal of the Korean Ophthalmological Society 2019;60(6):575-581.
DOI: https://doi.org/10.3341/jkos.2019.60.6.575    Published online June 15, 2019.
Effect and Prognostic Factors of Systemic Steroid Treatment for Strabismus Associated Thyroid Ophthalmopathy.
Gwang Rae Shin, Dae Hyun Kim
1Barun Eye Clinic, Gwangju, Korea.
2Department of Ophthalmology, Chosun University School of Medicine, Gwangju, Korea. eyekim@chosun.ac.kr
스테로이드 전신투여가 갑상샘눈병증 연관 사시 예후에 미치는 영향 분석
신광래1·김대현2
바른안과의원1, 조선대학교 의과대학 안과학교실2
Correspondence:  Dae Hyun Kim,
Email: eyekim@chosun.ac.kr
Received: 10 January 2019   • Revised: 28 February 2019   • Accepted: 17 May 2019
Abstract
PURPOSE
To investigate the effect of steroid treatment on strabismus associated with thyroid ophthalmopathy. METHODS: The present retrospective study was conducted on 22 patients diagnosed with strabismus associated with thyroid ophthalmopathy, who were treated with steroids orally or intravenously and followed up for more than one year. Patients were divided into three groups for analysis: an improved group, with no strabismus at the final follow-up visit; a stable group, with no change in the strabismus angle; and a deteriorated group, in which the strabismus angle had worsened. We investigated the characteristics of each group. RESULTS: In the gender/sex distribution of the 22 patients, 11 of the 15 patients in the improved or stable group were female; six of seven patients in the deteriorated group were male (p = 0.012). Two of the 15 patients in the improved or stable group had a smoking history. However, none smoked after the treatment had started. On the other hand, five of seven patients in the deteriorated group had a smoking history and continued to smoke during and after treatment (p = 0.001). No significant between-group differences were observed with respect to age, diplopia period, strabismus angle, or thyroid function level. CONCLUSIONS: Treatment with steroids may improve or stabilize strabismus associated with thyroid ophthalmopathy. However, the effect of treatment may differ, depending on whether the patient continues to smoke after treatment is initiated.
Key Words: Steroid treatment;Strabismus;Thyroid ophthalmopathy


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