J Korean Ophthalmol Soc > Volume 60(11); 2019 > Article
Journal of the Korean Ophthalmological Society 2019;60(11):1089-1097.
DOI: https://doi.org/10.3341/jkos.2019.60.11.1089    Published online November 15, 2019.
Associations between Retinal Nerve Fiber Layer Defect and Systemic Indices According to the KNHNES 2010–2012.
Suk Hoon Jung, Sooji Jeon, Chan Kee Park, Hae Young Lopilly Park
Department of Ophthalmology, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea. lopilly@catholic.ac.kr
국민건강영양조사 자료를 이용하여 분석한 망막신경섬유층 결손과 전신적인 지표와의 관계
정석훈 · 전수지 · 박찬기 · 박혜영
가톨릭대학교 의과대학 서울성모병원 안과학교실
Correspondence:  Hae-Young Lopilly Park, MD, PhD
Email: lopilly@catholic.ac.kr
Received: 7 March 2019   • Revised: 29 April 2019   • Accepted: 23 October 2019
Abstract
PURPOSE
To investigate the associations between retinal nerve fiber layer (RNFL) defects and systemic factors in the Korean population. METHODS: Based on data from the 5th Korean National Health and Nutritional Examination Survey (2010–2012), 2,999 non-glaucomatous patients and 424 glaucoma patients were included. We compared body mass index (BMI), blood pressure, and blood test values according to the presence and location of RNFL defects in the groups and analyzed whether these defects were associated with various underlying diseases. RESULTS: In the non-glaucomatous group, RNFL defects were significantly and linearly related with BMI (p = 0.035), systolic blood pressure (p < 0.001), diastolic blood pressure (p = 0.018), fasting blood glucose (p < 0.001), HbA1c (p < 0.001), serum ferritin (p = 0.008), and RNFL defects were also significantly associated with diabetes mellitus (p = 0.001), hypertension (p < 0.001), dyslipidemia (p = 0.003), a history of myocardial infarction or angina (p = 0.037), and migraines (p = 0.004). In the glaucoma group, patients who had superior RNFL defects had a significantly lower systolic blood pressure (p = 0.034) than patients who had inferior RNFL defects. The other systemic indices did not differ significantly between these two subgroups. Superior RNFL defects were significantly associated with diabetes mellitus (p = 0.047) and a history of cerebrovascular accident (p = 0.031). CONCLUSIONS: RNFL defects in both the non-glaucomatous and glaucoma groups were associated with systemic factors. We could identify that the possibility of RNFL defects can be deduced from these systemic abnormalities and active treatment is needed in abnormal systemic condition.
Key Words: Blood pressure;Diabetes mellitus;Hypertension;Retinal nerve fiber layer defect


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