J Korean Ophthalmol Soc > Volume 60(12); 2019 > Article
Journal of the Korean Ophthalmological Society 2019;60(12):1148-1154.
DOI: https://doi.org/10.3341/jkos.2019.60.12.1148    Published online December 15, 2019.
Clinical Symptoms and Signs of Dry Eye Disease after Allogeneic Hematopoietic Stem Cell Transplantation.
Jin Uk Beak, Min Ji Ha, Rowoon Yi, Young Sik Yoo, Hyun Seung Kim, Kyung Sun Na
Department of Ophthalmology, Yeouido St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea. drna@catholic.ac.kr
동종 조혈모세포이식술 후 안구건조증의 임상증상 및 징후
백진욱 · 하민지 · 이로운 · 유영식 · 김현승 · 나경선
가톨릭대학교 의과대학 여의도성모병원 안과학교실
Correspondence:  Kyung-Sun Na, MD, PhD
Email: drna@catholic.ac.kr
Received: 18 April 2019   • Revised: 16 May 2019   • Accepted: 6 December 2019
To identify the symptoms and signs of patients with dry eye disease (DED) after allogenic hematopoietic stem cell transplantation (HSCT) and analyze the correlations between these signs and symptoms. METHODS: We performed a retrospective study in 96 eyes of HSCT recipients with DED. Visual acuity, intraocular pressure, Schirmer test 1 (with anesthesia), tear osmolarity, tear break-up time, Ocular staining score (OSS, Oxford), and Ocular staining disease index (OSDI) were examined before and 1, 2, and 4 months after HSCT. RESULTS: A significant positive correlation was noted between changes in OSS and changes in OSDI. No ocular parameters showed significant correlations with Schirmer test values. Men more frequently described alleviation of symptoms greater than their objective results compared to women. CONCLUSIONS: Subjective symptoms alone may be insufficient when diagnosing ocular graft-versus-host disease. We recommend regular ophthalmologic examination after allo-HSCT. In addition, a baseline ocular profile of tear dynamics and ocular surface parameters should be conducted before allo-HSCT.
Key Words: Dry eye syndromes;Graft vs host disease;Hematopoietic stem cell transplantation

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