A Case of Miller Fisher Syndrome in a Pediatric Patient with Positive Anti-GQ1b IgG.

Kim, Eun Jee; Ha, Suk Gyu; Kim, Seung Hyun

doi:2016.57.3.528

J Korean Ophthalmol Soc > Volume 57(3); 2016 > Article

Case Report

Journal of the Korean Ophthalmological Society 2016;57(3):528-531.
DOI: https://doi.org/10.3341/jkos.2016.57.3.528 Published online March 15, 2016.

A Case of Miller Fisher Syndrome in a Pediatric Patient with Positive Anti-GQ1b IgG.

Eun Jee Kim, Suk Gyu Ha, Seung Hyun Kim

Department of Ophthalmology, Korea University College of Medicine, Seoul, Korea. ansaneye@hanmail.net

소아에서 발생한 항 GQ1b 항체 양성 밀러피셔증후군 1예

김은지⋅하석규⋅김승현

고려대학교 의과대학 안과학교실

Abstract

PURPOSE
To report a case of Miller Fisher syndrome in a pediatric patient with gastroenteritis associated with seroconversion of Campylobacter jejuni titer during the development of neurological symptoms and positive anti-GQ1b IgG. CASE SUMMARY: An 8-year-old male patient visited our clinic with bilateral ophthalmoplegia, diplopia, and ptosis of the right upper lid. He had experienced gastroenteritis one week previous, and antibodies to Campylobacter jejuni were detected in his plasma. Ophthalmic examination revealed a corrected visual acuity of 20/20 in both eyes. Ocular motor examination revealed limitations in all positions of gaze. Neurologic examination demonstrated areflexia and ataxia. The serologic anti-GQ1b IgG test was positive. Intravenous immunoglobulin and steroid pulse therapy were started. Extraocular movement, ptosis, and ataxia gradually improved after one month of treatment. CONCLUSIONS: We confirmed a case of Miller Fisher syndrome in a pediatric patient with bilateral ophthalmoplegia, ptosis, and a positive anti-GQ1b antibody test.

Key Words: Anti-GQ1b IgG antibody;Miller Fisher syndrome;Pediatric patient