Effect of 0.05% Cyclosporine A on the Ocular Surface after Photorefractive Keratectomy.

Kim, Yong Il; Koo, Sung Hyun; Ha, Sang Won; Lee, Gwang Ja; Lee, Kyoo Won; Park, Young Jeung

doi:2016.57.5.710

J Korean Ophthalmol Soc > Volume 57(5); 2016 > Article

Original Article

Journal of the Korean Ophthalmological Society 2016;57(5):710-717.
DOI: https://doi.org/10.3341/jkos.2016.57.5.710 Published online May 15, 2016.

Effect of 0.05% Cyclosporine A on the Ocular Surface after Photorefractive Keratectomy.

Yong Il Kim, Sung Hyun Koo, Sang Won Ha, Gwang Ja Lee, Kyoo Won Lee, Young Jeung Park

¹Cheil Eye Hospital, Daegu, Korea. eyepark9@naver.com
²Department of Ophthalmology, Dongkang Medical Center, Ulsan, Korea.

굴절교정레이저각막절제술 후 0.05% 사이클로스포린이 안구표면에 미치는 효과

김용일¹⋅구성현²⋅하상원¹⋅이광자¹⋅이규원¹⋅박영정¹

제일안과병원¹, 동강병원 안과²

Received: 3 September 2015 • Revised: 17 December 2015 • Accepted: 5 February 2016

Abstract

PURPOSE
To evaluate the effect of 0.05% cyclosporine A on the ocular surface after photorefractive keratectomy (PRK). METHODS: This retrospective study included 50 patients who underwent PRK. Patients were divided into two groups: 25 patients in group I were treated with topical 0.05% cyclosporine A with conventional medication, and 25 patients in group II were treated with conventional medication. Visual acuity (VA), tear break-up time (BUT), fluorescein staining score (F-stain), Schirmer I test, and ocular surface disease index (OSDI) were evaluated before surgery and 2 weeks, 1 month, 2 months, and 3 months after surgery. RESULTS: F-stain was significantly lower in group I than in group II at 2 weeks and 1 month (p < 0.05). There was no significant difference in uncorrected VA, BUT, Schirmer I test, or OSDI between the groups. However, group I showed a more effective pattern in dry eye. CONCLUSIONS: Combination treatment with 0.05% cyclosporine A was helpful for early ocular surface stability in patients with dry eye after PRK.

Key Words: Cyclosporine A;Dry eye;Ocular surface stability;Photorefractive keratectomy;Refractive surgery