J Korean Ophthalmol Soc > Volume 57(6); 2016 > Article
Journal of the Korean Ophthalmological Society 2016;57(6):863-875.
DOI: https://doi.org/10.3341/jkos.2016.57.6.863    Published online June 15, 2016.
Clinical Manifestations and Outcomes of Treatment in Cytomegalovirus Endotheliitis.
Young Jun Kim, Woong Sun Yoo, Yong Seop Han, Inyoung Chung, Seong Wook Seo, Ji Myong Yoo, Jong Moon Park, Min Chul Cho, Seong Jae Kim
1Department of Ophthalmology, Gyeongsang National University School of Medicine, Jinju, Korea. Maya12kim@naver.com
2Lee Seong Su Eye Center, Jinju, Korea.
3Gyeongsang Institute of Health Science, Gyeongsang National University, Jinju, Korea.
4Department of Laboratory Medicine, Gyeongsang National University College of Medicine, Jinju, Korea.
거대세포바이러스 각막내피염의 임상적 특징과 치료 경과
경상대학교 의학전문대학원 안과학교실1, 이성수 안과의원2, 경상대학교 건강과학연구원3, 경상대학교 의학전문대학원 진단검사의학과학교실4
Correspondence:  Seong-Jae Kim, MD, PhD
Email: Maya12kim@naver.com
Received: 14 January 2016   • Revised: 18 April 2016   • Accepted: 24 May 2016
To elucidate the clinical manifestations of cytomegalovirus (CMV) endotheliitis, and evaluate the outcomes of treatment in CMV endotheliitis. METHODS: We reviewed the medical records of 7 patients (8 eyes) who were diagnosed with CMV endotheliitis via a polymerase chain reaction (PCR) of aqueous humor and were treated with ganciclovir. RESULTS: Eight eyes of 7 patients were followed for a mean of 17.8 months. One patient had bilateral corneal endotheliitis. All eyes had coin-shaped keratoprecipitates and mild anterior chamber inflammation (1+~2+). All eyes had an absence of anterior segment inflammation 3 weeks after ganciclovir treatment. Following treatment, the mean visual acuity improved significantly from 0.60 ± 0.40 (log MAR) at baseline to 0.18 ± 0.18 (log MAR) at last follow-up. The mean intraocular pressure (IOP) decreased significantly from 30 mm Hg at baseline to 12 mm Hg at last visit. Two eyes had a recurrence of corneal endotheliitis, where one underwent penetrating keratoplasty and the other was treated with intravitreal ganciclovir injection. CONCLUSIONS: Patients with increased IOP and coin-shaped keratoprecipitates are suspected to have CMV endotheliitis, and PCR of aqueous humor is needed to diagnose CMV endotheliitis. More than 6 weeks of ganciclovir treatment might be effective for CMV endotheliitis and may help prevent recurrence.
Key Words: Cytomegalovirus;Endotheliitis;Ganciclovir

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