| Clinical Manifestations and Outcomes of Treatment in Cytomegalovirus Endotheliitis. |
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Young Jun Kim, Woong Sun Yoo, Yong Seop Han, Inyoung Chung, Seong Wook Seo, Ji Myong Yoo, Jong Moon Park, Min Chul Cho, Seong Jae Kim |
1Department of Ophthalmology, Gyeongsang National University School of Medicine, Jinju, Korea. Maya12kim@naver.com
2Lee Seong Su Eye Center, Jinju, Korea.
3Gyeongsang Institute of Health Science, Gyeongsang National University, Jinju, Korea.
4Department of Laboratory Medicine, Gyeongsang National University College of Medicine, Jinju, Korea. |
| 거대세포바이러스 각막내피염의 임상적 특징과 치료 경과 |
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김영준1⋅유웅선2⋅한용섭1,3⋅정인영1,3⋅서성욱1,3⋅유지명1,3⋅박종문1,3⋅조민철4⋅김성재1,3 |
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경상대학교 의학전문대학원 안과학교실1, 이성수 안과의원2, 경상대학교 건강과학연구원3, 경상대학교 의학전문대학원 진단검사의학과학교실4 |
Correspondence:
Seong-Jae Kim, MD, PhD
Email: Maya12kim@naver.com |
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Received: 14 January 2016 • Revised: 18 April 2016 • Accepted: 24 May 2016 |
| Abstract |
PURPOSE
To elucidate the clinical manifestations of cytomegalovirus (CMV) endotheliitis, and evaluate the outcomes of treatment in CMV endotheliitis. METHODS: We reviewed the medical records of 7 patients (8 eyes) who were diagnosed with CMV endotheliitis via a polymerase chain reaction (PCR) of aqueous humor and were treated with ganciclovir. RESULTS: Eight eyes of 7 patients were followed for a mean of 17.8 months. One patient had bilateral corneal endotheliitis. All eyes had coin-shaped keratoprecipitates and mild anterior chamber inflammation (1+~2+). All eyes had an absence of anterior segment inflammation 3 weeks after ganciclovir treatment. Following treatment, the mean visual acuity improved significantly from 0.60 ± 0.40 (log MAR) at baseline to 0.18 ± 0.18 (log MAR) at last follow-up. The mean intraocular pressure (IOP) decreased significantly from 30 mm Hg at baseline to 12 mm Hg at last visit. Two eyes had a recurrence of corneal endotheliitis, where one underwent penetrating keratoplasty and the other was treated with intravitreal ganciclovir injection. CONCLUSIONS: Patients with increased IOP and coin-shaped keratoprecipitates are suspected to have CMV endotheliitis, and PCR of aqueous humor is needed to diagnose CMV endotheliitis. More than 6 weeks of ganciclovir treatment might be effective for CMV endotheliitis and may help prevent recurrence. |
| Key Words:
Cytomegalovirus;Endotheliitis;Ganciclovir |
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