Diagnostic Ability of Macular Ganglion Cell Layer Measurements in Glaucoma Using Swept Source Optical Coherence Tomography.

Lee, Eung Suk; Chang, Jee Ho; Park, Tae Kwan; Ohn, Young Hoon; Park, Ka Hee

doi:2016.57.6.941

J Korean Ophthalmol Soc > Volume 57(6); 2016 > Article

Original Article

Journal of the Korean Ophthalmological Society 2016;57(6):941-950.
DOI: https://doi.org/10.3341/jkos.2016.57.6.941 Published online June 15, 2016.

Diagnostic Ability of Macular Ganglion Cell Layer Measurements in Glaucoma Using Swept Source Optical Coherence Tomography.

Eung Suk Lee, Jee Ho Chang, Tae Kwan Park, Young Hoon Ohn, Ka Hee Park

Department of Ophthalmology, Bucheon Hospital, Soonchunhyang University College of Medicine, Bucheon, Korea. khpark@schmc.ac.kr

녹내장에서 파장가변 빛간섭단층촬영을 이용한 황반부 신경절세포층의 진단력

이응석⋅장지호⋅박태관⋅온영훈⋅박가희

순천향대학교 의과대학 부천병원 안과학교실

Correspondence: Ka Hee Park,
Email: khpark@schmc.ac.kr

Received: 12 November 2015 • Revised: 3 March 2016 • Accepted: 14 April 2016

Abstract

PURPOSE
To evaluate diagnostic ability of macular ganglion cell complex (mGCC), macular ganglion cell inner plexiform layer (mGCIPL) measurements in glaucoma using swept source deep range imaging optical coherence tomography (DRI OCT-1, Topcon Co., Tokyo, Japan). METHODS: From August of 2014 to July of 2015, 109 eyes of 109 subjects were assessed for the average thickness and sectional thickness of both mGCC and mGCIPL to determine whether there exists any significant difference among advanced stage glaucoma group, early stage glaucoma group and normal group in Swept source OCT. Comparisons were also made between the above measurements and circumpapillary retinal nerve fiber layer (cpRNFL) thickness measurements in their diagnostic accuracy, sensitivity, and specificity. RESULTS: The diagnostic ability of mGCC based-mean thickness value (area under the curve [AUC] = 0.78/0.99) in detecting early stage glaucoma group as well as advanced stage group was not significantly different from that of cpRNFL thickness measurement. However, there was a significant difference in thickness between mGCIPL (AUC = 0.70) and cpRNFL in early stage glaucoma groups (p = 0.018). The sensitivities and specificities of mGCC were 0.95/0.97, and those of mGCIPL were 0.92/0.97, respectively. CONCLUSIONS: The two swept source OCT based methods measuring retinal ganglion cell layer thickness appeared to have a good diagnostic accuracy, high sensitivity and specificity in detecting glaucomatous eyes. Nevertheless, of the two methods, mGCC thickness measurement was more efficient in detecting early glaucomatous changes.

Key Words: Glaucoma;Macular ganglion cell and inner plexiform layer;Macular ganglion cell complex;Swept source optical coherence tomography