J Korean Ophthalmol Soc > Volume 57(8); 2016 > Article
Journal of the Korean Ophthalmological Society 2016;57(8):1260-1267.
DOI: https://doi.org/10.3341/jkos.2016.57.8.1260    Published online August 15, 2016.
Correlation between Trans-lamina Cribrosa Pressure Difference and Morphologic Parameters of Optic Disc in Normal Tension Glaucoma Patients.
Yu Jin Cheong, Kyung Eun Han, Kyu Ryong Choi
Department of Ophthalmology, Ewha Institute of Ophthalmology and Optometry, Ewha Womans University School of Medicine, Seoul, Korea. ckrey02@ewha.ac.kr
정상안압녹내장에서 경사상판압력차와 시신경유두의 구조적 지표와의 관련성
이화여자대학교 의학전문대학원 안과학교실 이화시과학연구센터
Correspondence:  Kyu Ryong Choi,
Email: ckrey02@ewha.ac.kr
Received: 21 April 2016   • Revised: 23 May 2016   • Accepted: 25 July 2016
To investigate the relationship between trans-lamina cribrosa pressure difference (TLCPD) and morphologic parameters of optic disc (OD) in normal tension glaucoma (NTG) patients. METHODS: Data from 31 NTG patients (31 eyes) and 29 controls (29 eyes) were analyzed retrospectively. Their cerebrospinal fluid pressure was estimated using diastolic pressure (DBP), body mass index (BMI) and age. TLCPD was defined as the difference of intraocular pressure (IOP) and the estimated cerebrospinal fluid pressure (ECSFP). Measurements of the rim area (RA), disc area (DA), average and vertical cup/disc (C/D) ratio, retinal nerve fiber layer thickness (RNFLT) and cup volume (CV) were taken for all patients using optical coherence tomography. The correlation between TLCPD and morphologic parameters of OD were assessed. RESULTS: There were no significant differences between the two groups in terms of age, DBP, IOP and spherical equivalent (SE) and BMI. The mean ECSFP was significantly higher in the controls (10.7 ± 2.8 vs. 12.2 ± 2.2 mm Hg, p = 0.031) and TLCPD was significantly higher in patients (2.4 ± 2.1 vs. 4.9 ± 3.7 mm Hg, p = 0.002). In the NTG group, there was a negative correlation between TLCPD and RA (r = -0.595) and positive correlations between TLCPD and the average C/D ratio (r = 0.504), vertical C/D ratio (r = 0.434) and CV (r = 0.420). Average RNLFT was also significantly correlated with TLCPD (r = -0.500) and RNFLT for four quadrants, except the nasal quadrant, in NTG patients. CONCLUSIONS: NTG patients had higher TLCPD. A higher TLCPD was associated with a narrower RA, larger C/D ratio, and thinner RNFLT.
Key Words: Estimated cerebrospinal fluid pressure;Normal tension glaucoma;Optical coherence tomography;Rim area;Trans-lamina cribrosa pressure difference

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