J Korean Ophthalmol Soc > Volume 57(9); 2016 > Article
Journal of the Korean Ophthalmological Society 2016;57(9):1392-1399.
DOI: https://doi.org/10.3341/jkos.2016.57.9.1392    Published online September 15, 2016.
Cerebrospinal Fluid Pressure and Trans-lamina Cribrosa Pressure Difference in Open-angle Glaucoma: KNHANES V.
Yoon Kyung Kim, Undarmaa Tumurbaatar, Young Hoon Ohn, Seung Joo Ha, Ka Hee Park
1Department of Ophthalmology, Bucheon Hospital, Soonchunhyang University College of Medicine, Bucheon, Korea. ophkh@schmc.ac.kr
2Department of Ophthalmology, Seoul Hospital, Soonchunhyang University College of Medicine, Seoul, Korea.
개방각녹내장과 뇌척수압 및 사상판경유압력차의 관계: 제5기 국민건강영양조사 자료
김윤경1⋅Undarmaa Tumurbaatar1⋅온영훈1⋅하승주2⋅박가희1
순천향대학교 의과대학 부천병원 안과학교실1, 순천향대학교 의과대학 서울병원 안과학교실1
Correspondence:  Ka Hee Park,
Email: ophkh@schmc.ac.kr
Received: 28 April 2016   • Revised: 23 June 2016   • Accepted: 2 August 2016
To investigate the relationships between estimated cerebrospinal fluid pressure (CSFP) and trans-lamina cribrosa pressure difference (TLCPD) in open-angle glaucoma (OAG) in Korean population. METHODS: A total of 10,801 eyes were included from the Korean National Health and Nutrition Examination Survey V. All participants (aged 19 years or older) were classified as non-glaucomatous group, OAG suspect group and OAG group. CSFP was calculated as CSFP (mm Hg) = 0.44 body mass index (kg/m²) + 0.16 diastolic blood pressure (mm Hg) - 0.18 age (years) - 1.91. TLCPD was calculated by subtracting CSFP from intraocular pressure. RESULTS: The mean estimated CSFP was (8.7 ± 3.3 mm Hg vs. 11.6 ± 3.7 mm Hg, 11.2 ± 3.8 mm Hg vs. 11.6 ± 3.7 mm Hg) was lower, and the mean TLCPD (5.7 ± 4.4 mm Hg vs. 2.2 ± 4.4 mm Hg, 3 ± 4.7 mm Hg vs. 2.2 ± 4.4 mm Hg) was higher in the OAG group and in the OAG suspect group than in the non-glaucomatous control group, respectively (p < 0.001). After adjusting relating factor with CSFP and TLCPD using simple linear regression and multivariate analyses, the mean estimated CSFP was distributed lower (p < 0.001; beta: -0.12; B: -2.306; 95% confidence interval [CI]: -2.717, -1.895) in OAG group than in non-glaucomatous group and the mean TLCPD was distributed higher (p < 0.001; beta: 0.099; B: 1.349; 95% CI: 0.977, 1.72; p < 0.001; beta: 0.118; B: 2.776; 95% CI: 2.264, 3.289) in OAG suspect group and in OAG group than in non-glaucomatous group, respectively. CONCLUSIONS: Estimated CSFP and calculated TLCPD showed essential association with OAG presence. It supports the potential role of low CSFP in the pathogenesis of OAG.
Key Words: Cerebrospinal fluid pressure;Open-angle glaucoma;Trans-lamina cribrosa pressure difference

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