| To Report a Case of Tamoxifen-induced Retinopathy Diagnosed Using Spectral Domain Optical Coherence Tomography. |
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Jin Young Kwon, Do Gyun Kim |
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Department of Ophthalmology, Myongji Hospital, Seonam University College of Medicine, Goyang, Korea. Kimdk89@empas.com |
| 스펙트럼영역 빛간섭단층촬영을 이용한 타목시펜 망막병증의 진단과 경과관찰 증례 |
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권진영ㆍ김도균 |
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서남대학교 의과대학 명지병원 안과학교실 |
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| Abstract |
PURPOSE
To report a case of tamoxifen-induced retinopathy diagnosed using spectral domain optical coherence tomography (SD-OCT). CASE SUMMARY: A 44-year-old female presented with metamorphopsia in the left eye and binocular vision loss which started 5 months prior. She had no record of external trauma, diabetes or high blood pressure; however, she had been taking 21.9 g tamoxifen (20 mg/day) since October 2012 after a surgery of her left breast due to cancer. On the initial visit, fundus photography showed crystalline dot-like deposits in both parafoveae. Additionally, fluorescence angiography revealed a small leakage around the macular area. Optical coherence tomography (OCT) was obtained to differentiate from other diseases because fundus photography showed crystalline retinopathy. The OCT revealed a normal right eye but the left macula had a microcystic lesion. Based on the diagnosis of tamoxifen-induced retinopathy, the patient stopped taking tamoxifen. Three months after discontinuation of tamoxifen, fundus photography showed slightly decreased crystalline deposits in the parafoveal area and visual acuity of the right eye was slightly improved. However, SD-OCT showed a slightly aggravated disruption of the outer retina in both eyes. CONCLUSIONS: Although retinopathy caused by treatment with tamoxifen occurs infrequently, to prevent complications and irreversible damage, patients who take tamoxifen for medical purposes need to undergo a regular ophthalmologic examination. |
| Key Words:
Crystalline dot-like deposits;Microcystic lesion;Spectral domain optical coherence tomography (SD-OCT);Tamoxifen-induced retinopathy |
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