J Korean Ophthalmol Soc > Volume 57(12); 2016 > Article
Journal of the Korean Ophthalmological Society 2016;57(12):1834-1839.
DOI: https://doi.org/10.3341/jkos.2016.57.12.1834    Published online December 15, 2016.
Comparison of 1% Prednisolone and 0.1% Bromfenac Solutions for Preventing Macular Edema after Cataract Surgery.
Hyun Kyo Jeong, Woo Beom Shin, Kyoung Yul Seo, Jeihoon Lee
1Siloam Eye Hospital, Seoul, Korea. genialtoday@siloam.co.kr
2Department of Ophthalmology, Yonsei University College of Medicine, Seoul, Korea.
1% 프레드니솔론과 0.1% 브롬페낙 점안액의 백내장 수술 후 낭포황반부종 예방 효과 비교
실로암안과병원1, 연세대학교 의과대학 안과학교실2
To compare the clinical effectiveness of 1% Prednisolone acetate ophthalmic solution and 0.1% Bromfenac sodium hydrate ophthalmic solution on prevention of cystoid macular edema after cataract surgery. METHODS: A retrospective chart review of 349 patients who received phacoemulsification with intraocular lens implantation in Severance Hospital from July 2013 to January 2016 was performed. In these patients, 192 eyes received 1% Prednisolone acetate ophthalmic solution, and 157 eyes were treated with topical 0.1% Bromfenac sodium hydrate ophthalmic solution. The incidence and severity of cystoid macular edema (CME) were evaluated by retinal foveal thickness on optical coherence tomography for patients who showed best corrected visual acuity (BCVA) less than 0.5 (log MAR ≥ 0.3). RESULTS: There was no significant difference between the two groups in age (p = 0.708), sex (p = 0.977), or the side of operated eye (p = 0.443). The two groups showed BCVA 0.04 ± 0.09 (Steroid group) and 0.03 ± 0.07 (nonsteroidal anti-inflammatory drug [NSAID] group) at 1 month after the surgery and the difference was not significant (p = 0.947). One eye in the topical steroid group had cystoid macular edema, and 3 eyes in the steroid group showed elevated intraocular pressure (IOP) over 30 mm Hg. There were no IOP elevations or macular edema in the NSAID group. CONCLUSIONS: The results showed that 0.1% Bromfenac sodium hydrate ophthalmic solution had a similar effect to 1% Prednisolone acetate ophthalmic solution on preventing CME after cataract surgery. This indicates that topical NSAID can be considered along with topical steroids in order to prevent CME after cataract surgery.
Key Words: Cataract;Cystoid macular edema (CME);Nonsteroidal anti-inflammatory drug (NSAIDs)

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