J Korean Ophthalmol Soc > Volume 57(12); 2016 > Article
Journal of the Korean Ophthalmological Society 2016;57(12):1976-1980.
DOI: https://doi.org/10.3341/jkos.2016.57.12.1976    Published online December 15, 2016.
Treatment of Acute Retinal Necrosis with Acute Kidney Injury after Intravenous Antiviral Injection.
Sun Jin Hwang, Du Roo Kim, Min Ho Kang, Min Cheol Seong, Hee Yoon Cho, Yong Un Shin
Department of Ophthalmology, Hanyang University Guri Hospital, Hanyang University College of Medicine, Guri, Korea. Syu2000@hanmail.net
항바이러스제 정맥주사 후 급성 신손상이 발생한 급성망막괴사 환자의 치료
한양대학교 의과대학 한양대학교구리병원 안과학교실
In the present study, a case of acute retinal necrosis with acute renal injury due to high-dose intravenous antiviral injection which was treated by intravitreal ganciclovir injection is reported. CASE SUMMARY: A 46-year-old female visited our clinic complaining of red eye and decreased vision in the right eye. At the first visit, her corrected visual acuity was finger count in the right eye, and 20/20 in the left eye. Fundus examination of the right eye revealed multiple peripheral arterial occlusion, papilledema, and whitish necrotic infiltration at the periphery. Clinically diagnosed as acute retinal necrosis, the patient was started on intravenous acyclovir. Two days after injection, her serum creatinine level increased, therefore, intravenous acyclovir was discontinued and she was started on intravitreal ganciclovir. Five days after the intravenous injection was discontinued, the serum creatinine level returned to normal range. Four months after the first visit, visual acuity was 20/100 and no recurrence was observed. CONCLUSIONS: Intravitreal ganciclovir injection can be an effective alternative in patients with acute retinal necrosis and poor kidney function.
Key Words: Acute renal injury;Acute retinal necrosis;Acyclovir;Antiviral;Ganciclovir

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