| Correlation Analysis of Tear Film Lipid Layer Thickness and Ocular Surface Disease Index. |
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Rae Young Kim, Kyung Sun Na, Yu Li Park, Hyun Seung Kim |
1Department of Ophthalmology, College of Medicine, The Catholic University of Korea, Seoul, Korea. Sara514@catholic.ac.kr
2Department of Ophthalmology, The Catholic University of Korea Yeouido St. Mary's Hospital, Seoul, Korea. |
| 눈물 지질층 두께와 안구표면임상인자 간의 상관관계 분석 |
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김래영1⋅나경선1,2⋅박율리1,2⋅김현승1,2 |
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가톨릭대학교 의과대학 안과학교실1, 가톨릭대학교 여의도성모병원 안과2 |
Correspondence:
Hyun Seung Kim,
Email: Sara514@catholic.ac.kr
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Received: 17 November 2016 • Revised: 6 May 2017 • Accepted: 27 June 2017 |
| Abstract |
PURPOSE
To analyze the relationship between ocular surface disease index and tear film lipid layer thickness (LLT) using a LipiView II® (LipiView® Ocular Surface Interferometer, TearScience®, Morrisville, NC, USA) interferometer. METHODS: Forty-nine patients diagnosed with dry eye syndrome were recruited for this prospective study. Patients completed ocular surface disease index questionnaires. We performed slit lamp examination, Schirmer test, corneal and conjunctival fluorescein staining, measured tear film break-up time, and graded meibomian gland dysfunction. Tear LLT, blinking time, and dynamic meibomian imaging were analyzed using a LipiView II® ocular interferometer. To control for missing data, we analyzed four sets of imputated data via the multiple imputation method and performed Pearson correlation analysis. Patients were assigned to one of two LLT categories (LLT < 60 or LLT ≥ 60) and Chi-square test was performed. RESULTS: Among ocular surface disease parameters, tear film break-up time (tBUT) had a statistically significant correlation with average and maximum LLT (average LLT; p = 0.008, 0.035, 0.006, 0.049, maximum LLT; p = 0.006, 0.042, 0.020, 0.049, Pearson correlation analysis with multiple imputation) but there was no significant correlation with minimum LLT (minimum LLT; p = 0.048, 0.090, 0.079, 0.039). Of the patients with a relatively thick average LLT or maximum LLT (LLT ≥ 60 nm), 80% and 88% had a tBUT < 10, respectively. Conversely, 39% and 47% of patients with relatively thin average LLT (LLT < 60 nm) had a tBUT < 10 (average LLT; p = 0.013, maximum LLT; p = 0.039). CONCLUSIONS: Average LLT and maximum LLT were significantly correlated with tBUT. Patients with a relatively thin average or maximum LLT tended to have a shorter tBUT. Based on these results, measuring tear film LLT using a LipiView II® interferometer may be useful in the diagnosis and follow-up of patients with evaporative dry eye. |
| Key Words:
Dry eye syndrome;Interferometry;Lipid layer thickness;Lipiview;Meibomian gland dysfunction |
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