Journal of the Korean Ophthalmological Society 1980;21(3):215-218.
Published online March 1, 1980.
Electron Microscopic Investigation of Finer Structurtes of Rabbit Retina on the Experimental Toxic Lesion.
Jae Chan Kim
Department of Ophthalmology, Chung Ang University, School of Medicine, Seoul, Korea.
가토망막의 실험적 중독성병변의 전자현미경학적 관찰
김재찬(Jae Chan Kim)
Abstract
Electron microscopic observation was carried out on the alterations of finer structures of retina following the daily intraperitoneal injections of BRC (benzenhexachloride) and combination of BRC with copper for 4 weeks and 6 weeks to the rabbit respectively. 1. In both groups, vesicle formation due to sporadic disintegration and elimination of axons in the nerve fiber layer appeared. 2. Formation of large vesicles was noticeable in the cytoplasm of retinal pigment epithelial cells in both 4 weeks and 6 weeks groups which was considered to be a relative enlargement of smooth surfaced endoplasmic reticulum (SER) by the increased enzymatic activities in response to the toxins. Focal thickening of Bruch's membrane in the group of 4 weeks and focal destruction of the Bruch's membrane in the group of 6 Weeks were observed. 3. Between the BRC inoculated group and ERC combined with copper inoculated group, no conspicuous difference in findings was recognized. More severe alterations of finer retinal structures in the 6 weeks group than in the 4 weeks group were demonstrated.


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