Analysis of Clinical Features and Prognostic Factors of Ocular Surface Squamous Neoplasia.

Jung, Hyun Ho; Yang, Jee Myung; Yoon, Kyung Chul

doi:2014.55.4.506

J Korean Ophthalmol Soc > Volume 55(4); 2014 > Article

Original Article

Journal of the Korean Ophthalmological Society 2014;55(4):506-512.
DOI: https://doi.org/10.3341/jkos.2014.55.4.506 Published online April 15, 2014.

Analysis of Clinical Features and Prognostic Factors of Ocular Surface Squamous Neoplasia.

Hyun Ho Jung, Jee Myung Yang, Kyung Chul Yoon

Department of Ophthalmology, Chonnam National University Medical School, Gwangju, Korea. kcyoon@jnu.ac.kr

안구표면 편평상피세포 암종의 임상양상과 예후 인자에 대한 분석

정현호⋅양지명⋅윤경철

Department of Ophthalmology, Chonnam National University Medical School, Gwangju, Korea

Abstract

PURPOSE
To analyze the clinical features and prognostic factors of ocular surface squamous neoplasia (OSSN). METHODS: A total of 31 eyes of 31 patients with suspected OSSN who were treated with excision and biopsy were retrospectively reviewed. Clinical features such as patient symptoms, invasion type, morphologic feature and size of lesion were analyzed. All patients were treated with simple excision or mitomycin C combination therapy. Factors affecting recurrence were evaluated. RESULTS: The most common symptom, invasion type, morphological feature, lesion size and histological diagnosis were foreign body sensation (38.7%), combined conjunctiva and cornea type (71.0%), gelatinous type (74.2%), 5 - 10 mm in largest diameter (45.2%) and intraepithelial neoplasia (51.6%), respectively. Age, sex, morphological features, lesion size and histological diagnosis had no effect on recurrence. Mitomycin C combination therapy was significantly associated with decreased recurrence compared to simple excision (p < 0.05). CONCLUSIONS: In OSSN, intraepithelial neoplasia was the most common subtype. Mitomycin C combination therapy was effective in decreasing recurrence.

Key Words: Mitomycin C;Ocular surface squamous neoplasia