J Korean Ophthalmol Soc > Volume 55(7); 2014 > Article
Journal of the Korean Ophthalmological Society 2014;55(7):978-983.
DOI: https://doi.org/10.3341/jkos.2014.55.7.978    Published online July 15, 2014.
Effect of Cyclosporin A on Tear Film and Corneal Aberration after Cataract Surgery.
Jei Hun Jeon, Hong Seok Kim, Ji Won Jung, Sang Chul Yoon, Kyoung Yul Seo, Hyung Keun Lee, Eung Kweon Kim, Tae Im Kim
The Institute of Vision Research, Department of Ophthalmology, Yonsei University College of Medicine, Seoul, Korea. TIKIM@yuhs.ac
백내장 수술 전후 0.05% 사이클로스포린 점안이 눈물막 및 각막수차에 미치는 영향
전제훈⋅김홍석⋅정지원⋅윤상철⋅서경률⋅이형근⋅김응권⋅김태임
The Institute of Vision Research, Department of Ophthalmology, Yonsei University College of Medicine, Seoul, Korea
Abstract
PURPOSE
To evaluate the efficacy of 0.05% cyclosporine A on tear film parameters and corneal aberration after cataract surgery. METHODS: Patients who underwent cataract surgery were divided into 2 groups. Patients in Group I (23 eyes) were treated with cyclosporine A from 1 week before surgery to 3 months after surgery. Patients in Group II (24 eyes) underwent surgery without cyclosporine treatment. Tear film break-up time (BUT), Schirmer's test I, Oxford scheme, Ocular surface disease index (OSDI), and corneal aberrations were evaluated before surgery and at 1 and 3 months after surgery. RESULTS: In Group I, BUT was significantly improved at 3 months (p = 0.026) after surgery compared with the preoperative value. OSDI decreased significantly at 1 (p = 0.033) and 3 months (p = 0.003) after surgery compared with the preoperative value. However, there were no significant differences between preoperative and postoperative values of BUT and OSDI in Group II. Schirmer's test results and the Oxford scheme were not significantly changed in either group. Preoperative root mean square (RMS) total values were not different between the 2 groups, but was different at postoperative 3 months (p = 0.015). Group I had a significantly lower value for total RMS than Group II. In Group I, Coma 7 (Z3(-1)) (p = 0.018) and spherical aberration (Z4(0)) (p = 0.031) were significantly decreased after surgery. In Group II, Trefoil 6 (Z3(-3)) (p = 0.033) was significantly increased after surgery. CONCLUSIONS: 0.05% cyclosporine A may be effective for improving dry eye syndrome and corneal aberration after cataract surgery.
Key Words: Cataract surgery;Corneal aberration;Cyclosporin;Dry eye


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