| The Effects of Commodified Growth Factor Products on the Fibrovascularization of Porous Polyethylene Orbital Implants. |
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Won Mo Gu, Joon Hyuk Choi, Jun Hyuk Son |
1Department of Ophthalmology, Yeungnam University College of Medicine, Daegu, Korea. sjh@med.yu.ac.kr
2Department of Pathology, Yeungnam University College of Medicine, Daegu, Korea. |
| 상품화된 성장인자 제품이 다공성 안와충전물의 섬유혈관화에 미치는 영향 |
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구원모1⋅최준혁2⋅손준혁1 |
Department of Ophthalmology, Yeungnam University College of Medicine1, Daegu, Korea
Department of Pathology, Yeungnam University College of Medicine2, Daegu, Korea |
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| Abstract |
PURPOSE
To investigate the effects of commodified growth factor products used clinically on fibrovascular ingrowth into porous polyethylene orbital implants. METHODS: Porous polyethylene orbital implant sheets (Medpor(R)) soaked with Nepidermin (Easyef(R)), Trafermin (Fiblast(R)), and normal saline were implanted into the backs of 18 Sprague-Dawley rats. The degree of fibrovascular ingrowth as observed using a light microscope was compared 1 and 2 weeks after implantation and was calculated as a percentage of the fibrovascular ingrowth length. RESULTS: One week after implantation, the percentage of fibrovascular ingrowth length was 25.33 +/- 5.43%, 22.56 +/- 5.30%, and 21.78 +/- 4.66% in the Easyef(R)-, Fiblast(R)- and normal saline-soaked groups. The degree of fibrovascularization was higher in the Easyef(R)-soaked group than in the other groups (p = 0.020, 0.012). Two weeks after implantation, the degree of fibrovascularization was 98.33 +/- 5.00%, 100.00 +/- 0.00%, and 95.89 +/- 4.57%, which was significantly higher in the Easyef(R)-, and Fiblast(R)-soaked groups than in normal saline-soaked group (p = 0.019, <0.001). CONCLUSIONS: Commodified growth factor products used in other areas selectively enhanced fibrovascular ingrowth to a greater degree and earlier in ophthalmic plastic and reconstructive surgery. |
| Key Words:
Basic fibroblast growth factor;Epidermal growth factor;Fibrovascularization;Porous polyethylene orbital implant |
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