The Change of Microaneurysm in Diabetic Retinopathy Patients Who Undergo Intravitreal Avastin (Bevacizumab) Injection.

Choi, Chang Wook; Lee, Seung Joon; Kang, Hye Ra; Yang, Yun Sik

doi:2014.55.10.1481

J Korean Ophthalmol Soc > Volume 55(10); 2014 > Article

Original Article

Journal of the Korean Ophthalmological Society 2014;55(10):1481-1486.
DOI: https://doi.org/10.3341/jkos.2014.55.10.1481 Published online October 15, 2014.

The Change of Microaneurysm in Diabetic Retinopathy Patients Who Undergo Intravitreal Avastin (Bevacizumab) Injection.

Chang Wook Choi, Seung Joon Lee, Hye Ra Kang, Yun Sik Yang

¹Department of Ophthalmology, Wonkwang University School of Medicine & Hospital, Wonkwang University School of Medicine, Iksan, Korea. ysyang@wonkwang.ac.kr
²Department of Ophthalmology, Presbyterian Medical Center, Jeonju, Korea.

당뇨망막병증에서 유리체강내 베바시주맙 주사 후 망막미세혈관류의 변화

최창욱¹⋅이승준¹⋅강혜라²⋅양연식¹

Department of Ophthalmology, Wonkwang University School of Medicine & Hospital, Wonkwang University School of Medicine¹, Iksan, Korea
Department of Ophthalmology, Presbyterian Medical Center², Jeonju, Korea

Abstract

PURPOSE
To evaluate microvascular change (microaneurysm) in diabetic retinopathy patients who undergo intravitreal bevacizumab injection using fluorescein angiography (FAG). METHODS: Thirty one eyes of 31 diabetic retinopathy patients undergoing intravitreal bevacizumab injection (1.25 mg/0.05 mL) in only 1 eye were included in this study. The control group (31 eyes) consisted of the fellow eyes. We excluded cased with intravitreal bevacizumab injection in both eyes and medial opacity obscuring three fundus image due to vitreous hemorrhage. The microaneurysmal change was analyzed at the same site the circle with optic disc radius and macula using FAG 2 to 4 months after injection. RESULTS: The average number of microaneurysms was 42.58 +/- 33.93 and significantly decreased to 28.74 +/- 28.06 after intravitreal bevacizumab injection (p < 0.05). The decrease of 35.70 +/- 24.79% in the treatment group was statistically higher than 13.95 +/- 38.21% in the control group with the fellow eyes (p < 0.05). CONCLUSIONS: In the present study, intravitreal bevacizumab injection reduced neovascularization, cystoid macular edema. Therefore this data can be used for future research on microvascular changes in the retina.

Key Words: Bebacizumab (Avastin);Diabetic retinopathy;Vascular endothelial growth factor (VEGF)