J Korean Ophthalmol Soc > Volume 56(3); 2015 > Article
Journal of the Korean Ophthalmological Society 2015;56(3):339-344.
DOI: https://doi.org/10.3341/jkos.2015.56.3.339    Published online March 15, 2015.
Clinical Efficacy of Topical 3% Diquafosol Tetrasodium in Short Tear Film Break-Up Time Dry Eye.
Hyun Ho Jung, Yeon Soo Kang, Mi Sun Sung, Kyung Chul Yoon
Department of Ophthalmology, Chonnam National University Medical School, Gwangju, Korea. kcyoon@jnu.ac.kr
눈물막파괴시간이 짧은 건성안에서 3% 디쿠아포솔나트륨 점안액의 임상효과
전남대학교 의과대학 안과학교실
To evaluate the clinical efficacy of topical diquafosol tetrasodium 3% ophthalmic solution in patients with short tear film break-up time (BUT) dry eye. METHODS: This prospective study involved 30 eyes in 30 patients with dry eye who had tear film BUT values < or =5 seconds and schirmer's 1 test > or =5 mm, and showed no improvement with non-preservative sodium hyaluronate (SH) 0.1% artificial tears. All patients were treated with topical diquafosol tetrasodium 3% 6 times a day, in addition to SH 0.1% artificial tears. Schirmer's 1 test, tear film BUT, keratoepitheliopathy score with fluorescein, conjunctival staining score with lissamine green, and Ocular surface disease index (OSDI) score were evaluated at before treatments, and 1 month and 3 months after treatments. RESULTS: Significant improvements of tear film BUT and OSDI were observed at 1 month and 3 months after diquafosol tetrasodium 3% administration. At before treatment, and followed up at 1 and 3 months, tear film BUTs were 3.3 +/- 1.2, 4.4 +/- 1.0 (p < 0.01) and 4.9 +/- 1.1 seconds (p < 0.01), respectively, and OSDI scores were 43.5 +/- 24.4, 34.6 +/- 25.0 (p = 0.01) and 26.7 +/- 21.5 (p < 0.01), respectively. There were no significant changes of Schirmer's score, keratoepitheliopathy, and conjunctival staining score. After diquafosol tetrasodium 3% administration, severe adverse effects were not found in any of the patients. CONCLUSIONS: Topical diquafosol tetrasodium 3% administration was shown to be an effective treatment for improvements of tear film stability and dry eye symptoms.
Key Words: Diquafosol tetrasodium 3%;Dry eye;Short tear film break-up time

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