| Protective Effect of Preoperative Intraocular Pressure Reduction on Corneal Endothelium in Cataract Surgery. |
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Yong Sun Ahn, Yang Kyung Cho |
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Department of Ophthalmology and Visual Science, The Catholic University of Korea College of Medicine, Seoul, Korea. yangkyeung@hanmail.net |
| 백내장 수술 전 안압 하강의 각막 내피세포 보호 효과 |
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안용선⋅조양경 |
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가톨릭대학교 의과대학 안과 및 시과학교실 |
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| Abstract |
PURPOSE
To evaluate whether intraocular pressure reduction by intravenous injection of mannitol before phacoemulsification-cataract surgery can have a protective effect on corneal endothelium. METHODS: Patients undergoing sequential bilateral cataract surgery were divided into 2 groups, 36 eyes with anterior chamber depth (ACD) < 2.50 mm (group A) and 44 eyes with ACD > or = 2.50 mm (group B). In each group, preoperative intravenous injection of mannitol was performed in 1 randomly selected eye of the patient. The specular microscopic examination including cell density (ECD), coefficient of variation (CV), hexagonality (HA) of corneal endothelium, and corneal thickness was performed on postoperative 1 day, 2 weeks, and 5 weeks. In each group, the parameters were compared between the eyes with mannitolization and the contralateral eyes without mannitolization. RESULTS: In group A, eyes with preoperative mannitolization showed significantly higher ECD at postoperative 1 day and 5 weeks and showed a significantly thinner cornea at postoperative 1 day than those without mannitolization (all p < 0.05). However, in group B, there was no significant difference of ECD, CV, HA, and corneal thickness between the eyes with and without mannitolization. CONCLUSIONS: Preoperative intraocular pressure reduction by mannitolization before phacoemulsification can protect the corneal endothelial cells and recover the early postoperative period visual acuity in eyes with shallow anterior chamber. |
| Key Words:
Corneal endothelium;Mannitol;Microphthalmos;Phacoemulsification;Shallow anterior chamber |
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