J Korean Ophthalmol Soc > Volume 56(5); 2015 > Article
Journal of the Korean Ophthalmological Society 2015;56(5):753-758.
DOI: https://doi.org/10.3341/jkos.2015.56.5.753    Published online May 15, 2015.
Measuring Blood Viscosity in Normal Tension Glaucoma Patients.
You Ra Kim, Ka Young Moon, Nam Chun Cho, Eui Young Kweon, Dong Wook Lee
1Department of Ophthalmology, Chonbuk National University Medical School, Jeonju, Korea. ldw@jbnu.ac.kr
2Research Institute of Clinical Medicine of Chonbuk National University-Biomedical Research Institute of Chonbuk National University Hospital, Jeonju, Korea.
정상 안압 녹내장 환자의 혈액 점도의 측정
김유라1⋅문가영1⋅조남천1,2⋅권의용1,2⋅이동욱1,2
전북대학교 의학전문대학원 안과학교실1, 전북대학교 임상의학연구소-전북대학교병원 의생명연구원2
Abstract
PURPOSE
Non-intraocular pressure (IOP) factors such as vascular factors have been identified as contributing to normal tension glaucoma. However, there is not an established range of haemorheological factors considered normal, nor are there standardized tests. In this study, we investigated differences in blood viscosity and haemorheological parameters between patients with normal tension glaucoma (NTG) and normal controls using a new instrument called the BVD-RO1 (BIO-VISCO. Inc., Jeonju, Korea). METHODS: Twenty patients with NTG and 20 age-matched normal controls were included in the study. Haemorheological parameters of the venous blood samples, including blood viscosity at the shear rates of 300 (high shear rate) and 1 (low shear rate) s-1 were measured using an automated scanning capillary tube viscometer. RESULTS: More hematocrit concentration was detected in the NTG group than in the control group (p < 0.05). Furthermore, higher blood viscosities at the high (p < 0.01) and low (p < 0.01) shear rates were found in the NTG group. CONCLUSIONS: The NTG patients differed in blood viscosity with the control group. This may signify the importance of hemodynamic factors in the pathogenesis of NTG.
Key Words: Blood viscosity;Normal tension glaucoma


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