J Korean Ophthalmol Soc > Volume 56(6); 2015 > Article
Journal of the Korean Ophthalmological Society 2015;56(6):815-822.
DOI: https://doi.org/10.3341/jkos.2015.56.6.815    Published online June 15, 2015.
Comparison of Ocular Adnexal Mantle Cell Lymphoma and MALT Lymphoma.
Jong Joo Lee, Min Su Kim, Hee Young Choi, Keun Sung Park, Sung Bok Lee
1Department of Ophthalmology, Chungnam National University, School of Medicine, Daejeon, Korea. sblee@cnu.ac.kr
2Department of Ophthalmology, Pusan National University School of Medicine, Busan, Korea.
3Eyelove Eye Center, Daejeon, Korea.
안와부속기의 덮개 세포 림프종과 MALT 림프종의 비교
이종주1⋅김민수1⋅최희영2⋅박근성3⋅이성복1
충남대학교 의과대학 안과학교실1, 부산대학교 의학전문대학원 안과학교실2, 대전 눈사랑안과3
Received: 2 October 2014   • Revised: 16 January 2015   • Accepted: 12 May 2015
Abstract
PURPOSE
Mantle cell lymphoma (MCL) is known to have systemic dissemination with poor prognosis, but very few cases have been reported in Korea. Therefore, we analyzed clinical features and prognosis of MCL by comparing 3 cases of ocular adnexal MCL and mucosa-associated lymphoid tissue (MALT) lymphoma. METHODS: The medical records of patients with ocular adnexal MALT lymphoma and MCL from Chungnam National University Hospital and Pusan National University Hospital from January 1999 to April 2014 were retrospectively reviewed. Immunohistochemical examination was selectively used to diagnose lymphoma subtypes. Systemic dissemination, treatment response, and recurrence were identified using radiological testing and bone marrow aspiration. RESULTS: This study included 39 patients with ocular and ocular adnexal MALT lymphoma and 1 patient with MCL from Chungnam National University Hospital and 53 patients with MALT lymphoma and 2 patients with MCL from Pusan National University Hospital. All 3 (100%) patients diagnosed with ocular adnexal MCL were over 60 years of age. However, 28 of 92 (30.4%) patients diagnosed with MALT lymphoma were over 60 years of age. In MALT lymphoma, 3 of 92 patients presented with systemic dissemination and most patients recovered with radiotherapy. Conversely, all 3 patients with MCL showed systemic dissemination and recurrence after radiotherapy or chemotherapy, therefore, additional chemotherapy was required. CONCLUSIONS: Contrary to MALT lymphoma, ocular and ocular adnexal MCL usually presented with systemic dissemination and complete remission was difficult even though many regimens of chemotherapy were attempted. Because MCL can be misdiagnosed as MALT lymphoma, careful evaluation should be performed.
Key Words: MALT lymphoma;Mantle cell lymphoma;Ocular adnexal lymphoma


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