| A Case of Progressive Outer Retinal Necrosis Treated by Combined Intravitreal Foscarnet and Ganciclovir. |
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Da Ye Choi, Soo Hyun Lee, Yae Jean Kim, Soo Han Choi, Eun Young Kim, Hong Hoe Koo, Sang Jin Kim |
1Department of Ophthalmology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea. sangjin.kim.md@gmail.com
2Department of Pediatrics, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.
3Department of Pediatric and Adolescent Medicine, Hallym University Dongtan Sacred Heart Hospital, Hallym University College of Medicine, Hwaseong, Korea.
4Department of Pharmacology, Chung-ang University College of Pharmacy, Seoul, Korea. |
| 유리체강내 간시클로버와 포스카네트 병합 치료로 호전된 진행성외망막괴사 1예 |
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최다예1⋅이수현2⋅김예진2⋅최수한3⋅김은영4⋅구홍회2⋅김상진1 |
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성균관대학교 의과대학 삼성서울병원 안과학교실1, 성균관대학교 의과대학 삼성서울병원 소아청소년과학교실2, 한림대학교 의과대학 한림대학교 동탄성심병원 소아청소년과학교실3, 중앙대학교 약학대학 약리학교실 |
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Received: 24 October 2014 • Revised: 8 December 2014 • Accepted: 20 April 2015 |
| Abstract |
PURPOSE
To report a case of progressive outer retinal necrosis treated by combined intravitreal foscarnet and ganciclovir. CASE SUMMARY: A 11-year-old male with a history of chemotherapy and cord blood transplantation due to precursor T-cell leukemia developed Herpes zoster lesion on his forehead and rapidly progressing peripheral retinal necrosis without vasculitis in the right eye. Varicella-Zoster virus was confirmed in his cerebrospinal fluid using polymerase chain reaction (PCR); and the patient was diagnosed with progressive outer retinal necrosis. Despite combined treatment with intravenous acyclovir and foscarnet and intravitreal foscarnet, retinal necrosis progressed to retinal detachment and total retinal necrosis. During follow-up, new retinal necrosis was observed in his left eye. The patient was started on combined intravenous and intravitreal foscarnet and ganciclovir; retinal necrosis in the left eye regressed and posterior pole was spared. With subsequent oral valganciclovir and intravitreal foscarnet and ganciclovir, the remaining retina was preserved with maintained vision. |
| Key Words:
Combined intravitreal antiviral treatment;Progressive outer retinal necrosis |
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