Correlation between Visual Outcomes and Pre-Treatment Factors Including Hyperreflective Foci in Neovascular Age-Related Macular Degeneration.

Lee, Hyung Woo; Kim, Hyung Chan

doi:2015.56.8.1188

J Korean Ophthalmol Soc > Volume 56(8); 2015 > Article

Original Article

Journal of the Korean Ophthalmological Society 2015;56(8):1188-1194.
DOI: https://doi.org/10.3341/jkos.2015.56.8.1188 Published online August 15, 2015.

Correlation between Visual Outcomes and Pre-Treatment Factors Including Hyperreflective Foci in Neovascular Age-Related Macular Degeneration.

Hyung Woo Lee, Hyung Chan Kim

Department of Ophthalmology, Konkuk University Medical Center, Konkuk University School of Medicine, Seoul, Korea. eyekim@kuh.ac.kr

나이관련황반변성 환자에서 빛간섭단층촬영의 고반사점 및 치료 전 인자들과 시력과의 연관성

이형우⋅김형찬

건국대학교 의학전문대학원 건국대학교병원 안과학교실

Received: 5 December 2014 • Revised: 13 April 2015 • Accepted: 4 June 2015

Abstract

PURPOSE
To investigate the correlation between hyperreflective foci (HF) on spectral domain optical coherence tomography (SD-OCT) at baseline and visual outcomes after intravitreal ranibizumab injection in neovascular age-related macular degeneration (nAMD). METHODS: We retrospectively reviewed the medical records of 44 eyes of 44 nAMD patients. The number of HF was counted according to the location of HF on SD-OCT: neurosensory retinal layer, outer retinal layer, and subretinal layer. Statistical correlations among final visual acuity (VA) and pretreatment OCT parameters including number of HF, foveal thickness (FT), thickness of choroidal neovascularization (CNV), the status of external limiting membrane, and photoreceptor inner and outer segments (IS/OS) were evaluated. RESULTS: The number of HF was reduced in all retinal layers in nAMD patients after treatment. In multivariate regression analysis, final VA was associated with baseline VA, number of subretinal HF, and IS/OS disruption length (p = 0.028, p = 0.046 and p = 0.009, respectively) in nAMD patients. The baseline number of subretinal HF was correlated with final FT and CNV thickness (p = 0.002 and p = 0.009, respectively). CONCLUSIONS: The baseline number of subretinal HF on SD-OCT might predict the final VA after intravitreal ranibizumab treatment in nAMD patients.

Key Words: Hyperreflective foci;Neovascular age-related macular degeneration;Ranibizumab;Spectral domain optical coherence tomography;Visual outcome