J Korean Ophthalmol Soc > Volume 56(8); 2015 > Article
Journal of the Korean Ophthalmological Society 2015;56(8):1248-1255.
DOI: https://doi.org/10.3341/jkos.2015.56.8.1248    Published online August 15, 2015.
The Effect of Corneal Biomechanical Factors on Ocular Pulse Amplitude in Normal Subjects.
Han Jo Kwon, Ji Woong Lee, Jong Hun Shin
Department of Ophthalmology, Pusan National University Hospital, Pusan National University School of Medicine, Busan, Korea. jjongggal@naver.com
정상인에서 각막 생체역학인자가 파스칼안압계를 이용한 안구박동크기에 미치는 영향
부산대학교 의학전문대학원 부산대학교병원 안과학교실
Received: 9 January 2015   • Revised: 19 February 2015   • Accepted: 19 June 2015
To investigate the influence of corneal biomechanical factors on ocular pulse amplitude measured using dynamic contour tonometry in normal subjects. METHODS: The study population consisted of normal subjects who visited the outpatient clinic from January, 2014 to July, 2014. Ocular pulse amplitude was measured using dynamic contour tonometry and corneal hysteresis (CH) and corneal resistance factor (CRF) were measured using an ocular response analyzer. We applied univariate and multivariate linear regressions to investigate the relationship between ocular pulse amplitude and corneal biomechanical factors and other ocular factors. RESULTS: Fifty eyes of 50 patients (average age 52.8 +/- 17.2 years) were examined. The average ocular pulse amplitude was 2.90 +/- 1.04 mm Hg and the CH and CRF were 10.44 +/- 1.96 mm Hg and 11.03 +/- 2.21 mm Hg, respectively. In univariate linear regression, factors influencing ocular pulse amplitude were ocular pressure based on CRF (beta = 0.280, p = 0.049), Goldmann applanation tonometry (beta = 0.293, p = 0.039), and spherical equivalent (beta = 0.283, p = 0.047), while in multivariate linear regression the only factor influencing ocular pulse amplitude was CRF (beta = 0.686, p = 0.042). CONCLUSIONS: A positive correlation between ocular pulse amplitude reflecting ocular perfusion pressure and CRF reflecting corneal elasticity was observed. Correlations between the 2 factors will be an important aspect in future studies regarding the influences of corneal biomechanical factors on ocular perfusion pressure in glaucoma patients.
Key Words: Corneal biomechanical factors;Dynamic contour tonometry;Ocular pulse amplitude

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